Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins. - sprookjes - yvandenbroek - TriplyDB

Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins.

Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins.

http://www.wikidata.org/entity/Q43670938

about

Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels Threshold-controlled ubiquitination of the EGFR directs receptor fate Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1 Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2 The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.A comprehensive pathway map of epidermal growth factor receptor signaling High precision NMR structure and function of the RING-H2 finger domain of EL5, a rice protein whose expression is increased upon exposure to pathogen-derived oligosaccharides Negative regulation of Lck by Cbl ubiquitin ligase The Cbl interactome and its functions Negative regulation of Lyn protein-tyrosine kinase by c-Cbl ubiquitin-protein ligase in Fc epsilon RI-mediated mast cell activation Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme.Regulation of the Src family kinase Lck by Hsp90 and ubiquitination SH3P2 in complex with Cbl and Src.TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin.Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src.Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1.Roles of E3 ubiquitin ligases in cell adhesion and migration.Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity.Myristoylation and membrane binding regulate c-Src stability and kinase activity Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways.Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity.c-Cbl acts as a mediator of Src-induced activation of the PI3K-Akt signal transduction pathway during TRAIL treatment.Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells.Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations.As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia.LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?The Cbl family: ubiquitin ligases regulating signaling by tyrosine kinases.The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor.The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants.

P2860

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P2860

Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins.

http://www.wikidata.org/entity/Q43670938

description

2001 nî lūn-bûn

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2001年の論文

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年學術文章

@yue

2001年學術文章

@zh-hant

name

Src-catalyzed phosphorylation ...... iquitination of both proteins.

@en

Src-catalyzed phosphorylation ...... iquitination of both proteins.

@nl

type

label

Src-catalyzed phosphorylation ...... iquitination of both proteins.

@en

Src-catalyzed phosphorylation ...... iquitination of both proteins.

@nl

prefLabel

Src-catalyzed phosphorylation ...... iquitination of both proteins.

@en

Src-catalyzed phosphorylation ...... iquitination of both proteins.

@nl

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P1433

Journal of Biological Chemistry

P1476

Src-catalyzed phosphorylation ...... iquitination of both proteins.

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P2093

A Houghton

http://www.w3.org/2001/XMLSchema#string

A Sanjay

http://www.w3.org/2001/XMLSchema#string

A Yoshimura

http://www.w3.org/2001/XMLSchema#string

H Zhang

http://www.w3.org/2001/XMLSchema#string

M Yokouchi

http://www.w3.org/2001/XMLSchema#string

R Baron

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S Komiya

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T Kondo

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P2860

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation

Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity

Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

Crystal structures of c-Src reveal features of its autoinhibitory mechanism

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

Three-dimensional structure of the tyrosine kinase c-Src

The ubiquitin system

P304

35185-35193

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scholarly article

P356

10.1074/JBC.M102219200

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P407

P433

37

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P478

276

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P577

2001-07-11T00:00:00Z

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P698

11448952

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P921

phosphorylation

protein ubiquitination