Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
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How bacteria control the CRISPR-Cas arsenal.Gene Editing in Human Lymphoid Cells: Role for Donor DNA, Type of Genomic Nuclease and Cell Selection Method.Deep mutational scanning of S. pyogenes Cas9 reveals important functional domains.Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci.Type II-C CRISPR-Cas9 Biology, Mechanism, and Application.Applications of Alternative Nucleases in the Age of CRISPR/Cas9.In vivo genome editing in animals using AAV-CRISPR system: applications to translational research of human disease.High-Throughput Approaches to Pinpoint Function within the Noncoding Genome.The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit.Partial DNA-guided Cas9 enables genome editing with reduced off-target activity.Electroporation of mice zygotes with dual guide RNA/Cas9 complexes for simple and efficient cloning-free genome editing.The Council of Europe should not reaffirm the ban on germline genome editing in humans.Efficient and Scalable Precision Genome Editing in Staphylococcus aureus through Conditional Recombineering and CRISPR/Cas9-Mediated Counterselection.Improving CRISPR-Cas specificity with chemical modifications in single-guide RNAs.A highly specific SpCas9 variant is identified by in vivo screening in yeast.Precise Cas9 targeting enables genomic mutation prevention.Potential high-frequency off-target mutagenesis induced by CRISPR/Cas9 in Arabidopsis and its prevention.Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation.Microhomology-assisted scarless genome editing in human iPSCs.Evolved Cas9 variants with broad PAM compatibility and high DNA specificity.Insights into maize genome editing via CRISPR/Cas9.CRISPR/Cas9 -mediated gene knockout of Anopheles gambiae FREP1 suppresses malaria parasite infection.CRISPR/Cas9 and Genome Editing for Viral Disease-Is Resistance Futile?Feasibility of a Conditional Knockout System for Chlamydia Based on CRISPR Interference.Real-time observation of flexible domain movements in CRISPR-Cas9.Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity.While it is not deliberate, much of today's biomedical research contains logical and technical flaws, showing a need for corrective action.Naxos disease: from the origin to today.Inducible high-efficiency CRISPR-Cas9-targeted gene editing and precision base editing in African trypanosomes.Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 with improved proof-reading enhances homology-directed repair.A large-scale whole-genome sequencing analysis reveals highly specific genome editing by both Cas9 and Cpf1 (Cas12a) nucleases in rice.Directed evolution of CRISPR-Cas9 to increase its specificityIncreasing Cas9-mediated homology-directed repair efficiency through covalent tethering of DNA repair templateEx Vivo COL7A1 Correction for Recessive Dystrophic Epidermolysis Bullosa Using CRISPR/Cas9 and Homology-Directed RepairGene editing in the context of an increasingly complex genomeHigh fidelity CRISPR/Cas9 increases precise monoallelic and biallelic editing events in primordial germ cellsCRISPR/Cas9 System: A Bacterial Tailor for Genomic EngineeringBlossom of CRISPR technologies and applications in disease treatmentDiverse target gene modifications in Plasmodium falciparum using Bxb1 integrase and an intronic attBOncolytic Virus-Mediated RAS Targeting in Rhabdomyosarcoma
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P2860
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
description
2017 nî lūn-bûn
@nan
2017年の論文
@ja
2017年学术文章
@wuu
2017年学术文章
@zh
2017年学术文章
@zh-cn
2017年学术文章
@zh-hans
2017年学术文章
@zh-my
2017年学术文章
@zh-sg
2017年學術文章
@yue
2017年學術文章
@zh-hant
name
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
@en
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
@nl
type
label
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
@en
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
@nl
prefLabel
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
@en
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
@nl
P2093
P2860
P356
P1433
P1476
Enhanced proofreading governs CRISPR-Cas9 targeting accuracy.
@en
P2093
Alexander A Sousa
J Keith Joung
Janice S Chen
Jennifer A Doudna
Lucas B Harrington
Moira M Welch
Samuel H Sternberg
Yavuz S Dagdas
P2860
P2888
P304
P356
10.1038/NATURE24268
P407
P577
2017-09-20T00:00:00Z
P6179
1091860712