ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours.

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Acinar cell plasticity and development of pancreatic ductal adenocarcinoma.Induced PTF1a expression in pancreatic ductal adenocarcinoma cells activates acinar gene networks, reduces tumorigenic properties, and sensitizes cells to gemcitabine treatment.

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Q38922230-285FC131-2A7C-490F-B987-DF767A01ACC6 Q55516479-88F6853A-8B30-4A51-BC93-BF6983B3233D

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ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours.

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http://www.wikidata.org/entity/Q46563062

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2013 nî lūn-bûn

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年學術文章

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ICAT is a novel Ptf1a interact ...... altered expression in tumours.

@en

ICAT is a novel Ptf1a interact ...... altered expression in tumours.

@nl

type

Item

label

ICAT is a novel Ptf1a interact ...... altered expression in tumours.

@en

ICAT is a novel Ptf1a interact ...... altered expression in tumours.

@nl

prefLabel

ICAT is a novel Ptf1a interact ...... altered expression in tumours.

@en

ICAT is a novel Ptf1a interact ...... altered expression in tumours.

@nl

P1476

ICAT is a novel Ptf1a interact ...... altered expression in tumours

@en

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Annie Rodolosse

http://www.w3.org/2001/XMLSchema#string

Claudio Bassi

http://www.w3.org/2001/XMLSchema#string

Francisco X Real

http://www.w3.org/2001/XMLSchema#string

M Luisa Campos

http://www.w3.org/2001/XMLSchema#string

Maria Scardoni

http://www.w3.org/2001/XMLSchema#string

Stefania Beghelli

http://www.w3.org/2001/XMLSchema#string

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The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules

The beta-catenin binding protein ICAT modulates androgen receptor activity

PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.

The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

The bHLH transcription factor Mist1 is required to maintain exocrine pancreas cell organization and acinar cell identity

Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development

p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos

Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas

Wnt/beta-catenin signaling is required for development of the exocrine pancreas

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395-405

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scholarly article

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10.1042/BJ20120873

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English

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http://www.w3.org/2001/XMLSchema#string

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451

http://www.w3.org/2001/XMLSchema#string

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Aldo Scarpa

Andrea Mafficini

Víctor Javier Sánchez-Arévalo Lobo

Cara J Gottardi

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2013-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

23339455

http://www.w3.org/2001/XMLSchema#string

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours.

about

P2860

P2860

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours.

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P1476

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P2860

P304

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P50

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P31

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P478

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P577

P698