p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos
about
Mutations in PTF1A cause pancreatic and cerebellar agenesisPTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.The crystal structure of the Split End protein SHARP adds a new layer of complexity to proteins containing RNA recognition motifsUtilizing past and present mouse systems to engineer more relevant pancreatic cancer modelsThe nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesisRNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factorsEarly pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complexGeneration and characterization of Ptf1a antiserum and localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of mouse pancreas development.Exdpf is a key regulator of exocrine pancreas development controlled by retinoic acid and ptf1a in zebrafish.Revealing transcription factors during human pancreatic β cell development.A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord.Next-generation sequencing identifies the Danforth's short tail mouse mutation as a retrotransposon insertion affecting Ptf1a expression.A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse.Cerebellar GABAergic progenitors adopt an external granule cell-like phenotype in the absence of Ptf1a transcription factor expression.Ptf1a binds to and activates area III, a highly conserved region of the Pdx1 promoter that mediates early pancreas-wide Pdx1 expression.Study human pancreatic cancer in mice: how close are they?Differential ability of Ptf1a and Ptf1a-VP16 to convert stomach, duodenum and liver to pancreasCombined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinomaOn the origin of the beta cell.Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.MIST1 and PTF1 Collaborate in Feed-forward Regulatory Loops that Maintain the Pancreatic Acinar Phenotype in Adult Mice.Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling.Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cellsThe bHLH domain of Mistl is sufficient to activate gene transcription.Combined ectopic expression of Pdx1 and Ptf1a/p48 results in the stable conversion of posterior endoderm into endocrine and exocrine pancreatic tissue.Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord.Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex.Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A.Pleiotropic Roles of PDX-1 in the PancreasMultiple transcriptional mechanisms control Ptf1a levels during neural development including autoregulation by the PTF1-J complex.RNA-seq methods for identifying differentially expressed gene in human pancreatic islet cells treated with pro-inflammatory cytokines.ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours.Notch Signaling in Development, Tissue Homeostasis, and Disease.Id3 modulates cellular localization of bHLH Ptf1-p48 protein.
P2860
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P2860
p48 subunit of mouse PTF1 binds to RBP-Jkappa/CBF-1, the intracellular mediator of Notch signalling, and is expressed in the neural tube of early stage embryos
description
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im April 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/04/01)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/04/01)
@nl
наукова стаття, опублікована у квітні 2001
@uk
مقالة علمية (نشرت في أبريل 2001)
@ar
name
p48 subunit of mouse PTF1 bind ...... al tube of early stage embryos
@ast
p48 subunit of mouse PTF1 bind ...... al tube of early stage embryos
@en
p48 subunit of mouse PTF1 bind ...... al tube of early stage embryos
@nl
type
label
p48 subunit of mouse PTF1 bind ...... al tube of early stage embryos
@ast
p48 subunit of mouse PTF1 bind ...... al tube of early stage embryos
@en
p48 subunit of mouse PTF1 bind ...... al tube of early stage embryos
@nl
prefLabel
p48 subunit of mouse PTF1 bind ...... al tube of early stage embryos
@ast
p48 subunit of mouse PTF1 bind ...... al tube of early stage embryos
@en
p48 subunit of mouse PTF1 bind ...... al tube of early stage embryos
@nl
P2093
P2860
P1433
P1476
p48 subunit of mouse PTF1 bind ...... al tube of early stage embryos
@en
P2093
M. Kawaichi
R. Nakayama
P2860
P304
P356
10.1046/J.1365-2443.2001.00422.X
P577
2001-04-01T00:00:00Z