Chaperone-dependent stabilization and degradation of p53 mutants.
about
Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometryDocking-dependent ubiquitination of the interferon regulatory factor-1 tumor suppressor protein by the ubiquitin ligase CHIPRegulation of Mutant p53 Protein ExpressionHeat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseasesNovel endogenous angiogenesis inhibitors and their therapeutic potentialRecent advances in the molecular diagnostics of gastric cancerThe rebel angel: mutant p53 as the driving oncogene in breast cancer.C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balancesCellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disordersHigh-content, high-throughput analysis of cell cycle perturbations induced by the HSP90 inhibitor XL888Functional interplay between MDM2, p63/p73 and mutant p53PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein.Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphomaPromoter complexity and tissue-specific expression of stress response components in Mytilus galloprovincialis, a sessile marine invertebrate species.The Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesA novel p53 phosphorylation site within the MDM2 ubiquitination signal: I. phosphorylation at SER269 in vivo is linked to inactivation of p53 function.Protein mislocalization: mechanisms, functions and clinical applications in cancer.A novel p53 phosphorylation site within the MDM2 ubiquitination signal: II. a model in which phosphorylation at SER269 induces a mutant conformation to p53Heat shock proteins and Drosophila aging.Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.The Unfolded Protein Response, Degradation from Endoplasmic Reticulum and CancerPreferential binding of hot spot mutant p53 proteins to supercoiled DNA in vitro and in cells.Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cellsExpression and significance of CHIP in canine mammary gland tumors.It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.Sensitization of multidrug-resistant human cancer cells to Hsp90 inhibitors by down-regulation of SIRT1.Ribophorin II regulates breast tumor initiation and metastasis through the functional suppression of GSK3β.CHIP represses myocardin-induced smooth muscle cell differentiation via ubiquitin-mediated proteasomal degradation.p53: a molecular marker for the detection of cancer.Hsp90 inhibitors promote p53-dependent apoptosis through PUMA and Bax.Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses.Hsp70 structure, function, regulation and influence on yeast prions.Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma.S100A2 is a BRCA1/p63 coregulated tumour suppressor gene with roles in the regulation of mutant p53 stability.Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesisDNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway.Essential Roles of E3 Ubiquitin Ligases in p53 Regulation.Suppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo.p53-based cancer therapyDiverse roles of C-terminal Hsp70-interacting protein (CHIP) in tumorigenesis.
P2860
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P2860
Chaperone-dependent stabilization and degradation of p53 mutants.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Chaperone-dependent stabilization and degradation of p53 mutants.
@en
Chaperone-dependent stabilization and degradation of p53 mutants.
@nl
type
label
Chaperone-dependent stabilization and degradation of p53 mutants.
@en
Chaperone-dependent stabilization and degradation of p53 mutants.
@nl
prefLabel
Chaperone-dependent stabilization and degradation of p53 mutants.
@en
Chaperone-dependent stabilization and degradation of p53 mutants.
@nl
P2093
P2860
P356
P1433
P1476
Chaperone-dependent stabilization and degradation of p53 mutants.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1211010
P407
P577
2008-01-28T00:00:00Z
P5875
P6179
1043658637