Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1.
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A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen ProcessingEnzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IVCutting Edge: Coding single nucleotide polymorphisms of endoplasmic reticulum aminopeptidase 1 can affect antigenic peptide generation in vitro by influencing basic enzymatic properties of the enzymeIncreased decidual mRNA expression levels of candidate maternal pre-eclampsia susceptibility genes are associated with clinical severity.A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition.The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells.Impaired angiogenesis in aminopeptidase N-null mice.Genetic association with ERAP1 in psoriasis is confined to disease onset after puberty and not dependent on HLA-C*06.Silencing or inhibition of endoplasmic reticulum aminopeptidase 1 (ERAP1) suppresses free heavy chain expression and Th17 responses in ankylosing spondylitis.Investigating the genetic association between ERAP1 and ankylosing spondylitis.Histidine 379 of human laeverin/aminopeptidase Q, a nonconserved residue within the exopeptidase motif, defines its distinctive enzymatic propertiesCombined effects of ankylosing spondylitis-associated ERAP1 polymorphisms outside the catalytic and peptide-binding sites on the processing of natural HLA-B27 ligandsSingle Nucleotide Polymorphisms of the ERAP1 Gene and Risk of NSCLC: A Comparison of Genetically Distant Populations, Chinese and Caucasian.Post-proteasomal and proteasome-independent generation of MHC class I ligands.ERAP1 in the pathogenesis of ankylosing spondylitis.The Behçet's disease-associated variant of the aminopeptidase ERAP1 shapes a low-affinity HLA-B*51 peptidome by differential subpeptidome processing.Functional Interaction of the Ankylosing Spondylitis-Associated Endoplasmic Reticulum Aminopeptidase 2 With the HLA-B*27 Peptidome in Human Cells.Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Polymorphism Relevant to Inflammatory Disease Shapes the Peptidome of the Birdshot Chorioretinopathy-Associated HLA-A*29:02 Antigen.Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages.Differences between disease-associated endoplasmic reticulum aminopeptidase 1 (ERAP1) isoforms in cellular expression, interactions with tumour necrosis factor receptor 1 (TNF-R1) and regulation by cytokines.Dominant role of the ERAP1 polymorphism R528K in shaping the HLA-B27 Peptidome through differential processing determined by multiple peptide residues.Functional Genomics and Its Bench-to-Bedside Translation Pertaining to the Identified Susceptibility Alleles and Loci in Ankylosing Spondylitis.ERAP1 rs30187 single nucleotide polymorphism does not confer disease susceptibility in North Indian children with enthesitis-related arthritis.Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo.Secretion of endoplasmic reticulum aminopeptidase 1 is involved in the activation of macrophages induced by lipopolysaccharide and interferon-gammaFocus on Brain Angiotensin III and Aminopeptidase A in the Control of Hypertension.Is LGI2 the candidate gene for partial epilepsy with pericentral spikes?The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases.ERAP1 Gene Expression Is Influenced by Nonsynonymous Polymorphisms Associated With Predisposition to Spondyloarthritis.Association of ERAP1 Allelic Variants with Risk of Ankylosing SpondylitisThe association between seven ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis involving 8,530 cases and 12,449 controls.Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A.Bioinformatics analysis of genetic variants of endoplasmic reticulum aminopeptidase 1 in ankylosing spondylitis.A polymorphism in ERAP1 is associated with susceptibility to ankylosing spondylitis in a Turkish population.Ranking the contribution of ankylosing spondylitis-associated ERAP1 polymorphisms to shaping the HLA-B*27 peptidome.Exploring ankylosing spondylitis-associated ERAP1, IL23R and IL12B gene polymorphisms in subphenotypes of psoriatic arthritisGenetic diversity at endoplasmic reticulum aminopeptidases is maintained by balancing selection and is associated with natural resistance to HIV-1 infectionThe role of polymorphic ERAP1 in autoinflammatory disease
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P2860
Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
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2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
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2006年學術文章
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2006年學術文章
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name
Reduced activity of the hypert ...... e (A-LAP)/ER-aminopeptidase-1.
@en
Reduced activity of the hypert ...... derived leucine aminopeptidase
@nl
type
label
Reduced activity of the hypert ...... e (A-LAP)/ER-aminopeptidase-1.
@en
Reduced activity of the hypert ...... derived leucine aminopeptidase
@nl
prefLabel
Reduced activity of the hypert ...... e (A-LAP)/ER-aminopeptidase-1.
@en
Reduced activity of the hypert ...... derived leucine aminopeptidase
@nl
P2093
P2860
P1433
P1476
Reduced activity of the hypert ...... e (A-LAP)/ER-aminopeptidase-1.
@en
P2093
Akira Hattori
Masafumi Tsujimoto
Yasuhiro Ishii
Yoshikuni Goto
P2860
P304
P356
10.1016/J.FEBSLET.2006.02.041
P407
P577
2006-02-24T00:00:00Z