The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
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TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy.Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia.Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging.Amyloid-β Homeostasis Bridges Inflammation, Synaptic Plasticity Deficits and Cognitive Dysfunction in Multiple Sclerosis.Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype.Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy.Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan.Innate immune alterations are elicited in microglial cells before plaque deposition in the Alzheimer's disease mouse model 5xFAD.Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes.The Role of Microglia and Macrophages in CNS Homeostasis, Autoimmunity, and Cancer.Differential contribution of microglia and monocytes in neurodegenerative diseases.Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease.Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy.Neurodegenerative signature.Neuroinflammation: Microglia and T Cells Get Ready to Tango.Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.ApoE facilitates the microglial response to amyloid plaque pathology.Integrated biology approach reveals molecular and pathological interactions among Alzheimer's Aβ42, Tau, TREM2, and TYROBP in Drosophila models.Brain-Resident Microglia and Blood-Borne Macrophages Orchestrate Central Nervous System Inflammation in Neurodegenerative Disorders and Brain Cancer.TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant TREM2R47H on murine myeloid cell function.The role of TAM family receptors and ligands in the nervous system: From development to pathobiology.Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of Nf1 low-grade glioma growth.Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson's Disease?Microglia and Beyond: Innate Immune Cells As Regulators of Brain Development and Behavioral Function.Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.Neuronal Dysfunction and Behavioral Abnormalities Are Evoked by Neural Cells and Aggravated by Inflammatory Microglia in Peroxisomal β-Oxidation Deficiency.A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.Automated Morphological Analysis of Microglia After Stroke.Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.Apolipoprotein E Deficiency Exacerbates Spinal Cord Injury in Mice: Inflammatory Response and Oxidative Stress Mediated by NF-κB Signaling Pathway.The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.Comparing Effects of Transforming Growth Factor β1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels.Chronic stress as a risk factor for Alzheimer's disease: Roles of microglia-mediated synaptic remodeling, inflammation, and oxidative stress.Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer's disease-related proteins.Neuronal integrity and complement control synaptic material clearance by microglia after CNS injuryMicroglia in Alzheimer's diseaseCommentary: Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human HerpesvirusEpothilone B Benefits Nigral Dopaminergic Neurons by Attenuating Microglia Activation in the 6-Hydroxydopamine Lesion Mouse Model of Parkinson's DiseaseMicroglia in Alzheimer's Disease: A Role for Ion Channels
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P2860
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
description
2017 nî lūn-bûn
@nan
2017年の論文
@ja
2017年学术文章
@wuu
2017年学术文章
@zh-cn
2017年学术文章
@zh-hans
2017年学术文章
@zh-my
2017年学术文章
@zh-sg
2017年學術文章
@yue
2017年學術文章
@zh
2017年學術文章
@zh-hant
name
The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.
@en
The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.
@nl
type
label
The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.
@en
The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.
@nl
prefLabel
The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.
@en
The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.
@nl
P2093
P2860
P50
P1433
P1476
The TREM2-APOE Pathway Drives ...... in Neurodegenerative Diseases.
@en
P2093
Anna Worthmann
Bogdan Budnik
Caroline Baufeld
Charlotte Madore
Cynthia Lemere
David J Greco
Elaine O'Loughlin
Emily Tjon
Fargol Mazaheri
P2860
P304
566-581.e9
P356
10.1016/J.IMMUNI.2017.08.008
P407
P50
P577
2017-09-01T00:00:00Z