about
The transcription factor p53: not a repressor, solely an activatorThe p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genesHuman papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway.p53 and cell cycle dependent transcription of kinesin family member 23 (KIF23) is controlled via a CHR promoter element bound by DREAM and MMB complexes.The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes.The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism.Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex.Census and evaluation of p53 target genes.Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein.Transcriptional landscape of the human cell cycle.Does Arabidopsis thaliana DREAM of cell cycle control?p21 governs p53's repressive side.Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.RB, p130 and p107 differentially repress G1/S and G2/M genes after p53 activationConservation and divergence of the p53 gene regulatory network between mice and humansDREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
ricercatore
@it
հետազոտող
@hy
name
Martin Fischer
@ast
Martin Fischer
@en
Martin Fischer
@es
Martin Fischer
@nl
Martin Fischer
@sl
type
label
Martin Fischer
@ast
Martin Fischer
@en
Martin Fischer
@es
Martin Fischer
@nl
Martin Fischer
@sl
prefLabel
Martin Fischer
@ast
Martin Fischer
@en
Martin Fischer
@es
Martin Fischer
@nl
Martin Fischer
@sl
P108
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