ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis. - sprookjes - yvandenbroek - TriplyDB

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

http://www.wikidata.org/entity/Q50738205

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Genetic counseling for FTD/ALS caused by the C9ORF72 hexanucleotide expansion Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia Whole-genome sequencing reveals a coding non-pathogenic variant tagging a non-coding pathogenic hexanucleotide repeat expansion in C9orf72 as cause of amyotrophic lateral sclerosis Insulin-like growth factor-I for the treatment of amyotrophic lateral sclerosis A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis Neuropathology of non-Alzheimer degenerative disorders Toward precision medicine in amyotrophic lateral sclerosis Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases A comprehensive review of amyotrophic lateral sclerosis tRNA fragments in human health and disease Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis State of play in amyotrophic lateral sclerosis genetics The function of RNA-binding proteins at the synapse: implications for neurodegeneration Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons Crystal structures of murine angiogenin-2 and -3 - probing ‘structure - function’ relationships amongst angiogenin homologues Crystal structure of human angiogenin with an engineered loop exhibits conformational flexibility at the functional regions of the molecule TDP-43 aggregation in neurodegeneration: are stress granules the key?G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6 The complex molecular biology of amyotrophic lateral sclerosis (ALS)Lack of effect of methylene blue in the SOD1 G93A mouse model of amyotrophic lateral sclerosis Mechanisms of loss of functions of human angiogenin variants implicated in amyotrophic lateral sclerosis ACTH (Acthar Gel) Reduces Toxic SOD1 Protein Linked to Amyotrophic Lateral Sclerosis in Transgenic Mice: A Novel Observation Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci.Structural and functional implications of positive selection at the primate angiogenin gene.Genome-wide association reveals three SNPs associated with sporadic amyotrophic lateral sclerosis through a two-locus analysis.Transcription of angiogenin and ribonuclease 4 is regulated by RNA polymerase III elements and a CCCTC binding factor (CTCF)-dependent intragenic chromatin loop.Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem/Progenitor Cell Regulators.Roles of vascular endothelial growth factor in amyotrophic lateral sclerosis.Impact of presymptomatic genetic testing for familial amyotrophic lateral sclerosis.Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice An estimate of amyotrophic lateral sclerosis heritability using twin data.

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ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

http://www.wikidata.org/entity/Q50738205

description

2006 nî lūn-bûn

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2006年の論文

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年学术文章

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2006年學術文章

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2006年學術文章

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name

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

@en

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

@nl

type

label

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

@en

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

@nl

prefLabel

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

@en

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

@nl

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P1433

Nature Genetics

P1476

ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis.

@en

P2093

Carsten Russ

http://www.w3.org/2001/XMLSchema#string

Colette Donaghy

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Dairin Kieran

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K Ravi Acharya

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Matthew J Greenway

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Robert Swingler

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Susan Cashman

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Victor Patterson

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P2860

Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Alanine derivatives inhibit angiogenin-induced angiogenesis

Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonuclease

Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity

Role of lysines in human angiogenin: chemical modification and site-directed mutagenesis.

Identification of functional arginines in human angiogenin by site-directed mutagenesis.

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death.

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model.

Replacement of residues 8-22 of angiogenin with 7-21 of RNase A selectively affects protein synthesis inhibition and angiogenesis.

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411-413

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scholarly article

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10.1038/NG1742

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4

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38

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Karen E Morrison

Peter M Andersen

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2006-02-26T00:00:00Z

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16501576

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amyotrophic lateral sclerosis