about
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with ageKey role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell poolHuman reconstituting hematopoietic stem cells up-regulate Fas expression upon active cell cycling but remain resistant to Fas-induced suppression.SCExV: a webtool for the analysis and visualisation of single cell qRT-PCR data.Deficiency of oncoretrovirally transduced hematopoietic stem cells and correction through ex vivo expansion.Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt3- short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients.Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesisThe Cxcl12, periostin, and Ccl9 genes are direct targets for early B-cell factor in OP-9 stroma cells.Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineageA novel assay to trace proliferation history in vivo reveals that enhanced divisional kinetics accompany loss of hematopoietic stem cell self-renewalGenomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication.Niche recycling through division-independent egress of hematopoietic stem cellsFlow cytometry-based identification of immature myeloerythroid development.Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansionCell intrinsic alterations underlie hematopoietic stem cell aging.Mice with ribosomal protein S19 deficiency develop bone marrow failure and symptoms like patients with Diamond-Blackfan anemia.An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state.Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9Concise review: hematopoietic stem cell aging and the prospects for rejuvenationInduced hematopoietic stem cells: unlocking restrictions in lineage potential and self-renewal.Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCRThe transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor.Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis.Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias.Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cellsClonal reversal of ageing-associated stem cell lineage bias via a pluripotent intermediate.Shaping up a lineage--lessons from B lymphopoesis.Load and lock: the molecular mechanisms of B-lymphocyte commitment.Frequency determination of rare populations by flow cytometry: a hematopoietic stem cell perspective.NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements.ZFP521 regulates murine hematopoietic stem cell function and facilitates MLL-AF9 leukemogenesis in mouse and human cells.MLL-ENL-mediated leukemia initiation at the interface of lymphoid commitment.Molecular mechanisms underlying lineage bias in aging hematopoiesis.Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML.Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms.Disruption of the 5S RNP-Mdm2 interaction significantly improves the erythroid defect in a mouse model for Diamond-Blackfan anemia.Efficient oncoretroviral transduction of extended long-term culture-initiating cells and NOD/SCID repopulating cells: enhanced reconstitution with gene-marked cells through an ex vivo expansion approach.Probing hematopoietic stem cell function using serial transplantation: Seeding characteristics and the impact of stem cell purification.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
David Bryder
@ast
David Bryder
@en
David Bryder
@es
David Bryder
@nl
David Bryder
@sl
type
label
David Bryder
@ast
David Bryder
@en
David Bryder
@es
David Bryder
@nl
David Bryder
@sl
prefLabel
David Bryder
@ast
David Bryder
@en
David Bryder
@es
David Bryder
@nl
David Bryder
@sl
P106
P21
P31
P496
0000-0002-8761-4237