Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion - sprookjes - yvandenbroek - TriplyDB

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

http://www.wikidata.org/entity/Q33777928

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DNA Damage Response in Hematopoietic Stem Cell Ageing Ageing-Associated Oxidative Stress and Inflammation Are Alleviated by Products from Grapes Implications of Epigenetic Variability within a Cell Population for "Cell Type" Classification When stem cells grow old: phenotypes and mechanisms of stem cell aging Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications Genetic regulation of thymocyte progenitor aging Immunosenescence and organ transplantation Hematopoietic stem cell niche maintenance during homeostasis and regeneration Sirtuins in hematological aging and malignancy Age-dependent dysregulation of innate immunity STAT5 in hematopoietic stem cell biology and transplantation Mechanisms shaping the naïve T cell repertoire in the elderly - thymic involution or peripheral homeostatic proliferation?Transcription factor-mediated reprogramming toward hematopoietic stem cells Epigenetic regulation of hematopoietic stem cell aging Stem cell heterogeneity: implications for aging and regenerative medicine Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment The many faces of hematopoietic stem cell heterogeneity Tif1γ regulates the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells Republished: Non-heritable genetics of human disease: spotlight on post-zygotic genetic variation acquired during lifetime Non-heritable genetics of human disease: spotlight on post-zygotic genetic variation acquired during lifetime Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors Accumulation of DNA damage in the aged hematopoietic stem cell compartment Fgd5 identifies hematopoietic stem cells in the murine bone marrow.Stem cells are units of natural selection for tissue formation, for germline development, and in cancer development Aging of the microenvironment influences clonality in hematopoiesis.Stem and progenitor cell subsets are affected by JAK2 signaling and can be monitored by flow cytometry.The bone marrow at the crossroads of blood and immunity Aging of the innate immune system Dynamic equilibrium of heterogeneous and interconvertible multipotent hematopoietic cell subsets.Cdc42 and aging of hematopoietic stem cells.Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.Loss of P2Y₁₄ results in an arresting response to hematological stress Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle Some hematopoietic stem cells are more equal than others.Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis.Contribution of an aged microenvironment to aging-associated myeloproliferative disease.Progeroid syndromes: models for stem cell aging?

P2860

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P2860

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

http://www.wikidata.org/entity/Q33777928

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Functionally distinct hematopo ...... mechanism of clonal expansion

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Functionally distinct hematopo ...... mechanism of clonal expansion

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Functionally distinct hematopo ...... mechanism of clonal expansion

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Functionally distinct hematopo ...... mechanism of clonal expansion

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Functionally distinct hematopo ...... mechanism of clonal expansion

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PNAS.1000834107

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Functionally distinct hematopo ...... mechanism of clonal expansion

@en

P2093

Deepta Bhattacharya

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Derrick J Rossi

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Irving L Weissman

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Isabel Beerman

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Sasan Zandi

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P2860

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation.

Cell intrinsic alterations underlie hematopoietic stem cell aging.

Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness.

The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets.

Long-term propagation of distinct hematopoietic differentiation programs in vivo.

Hematopoiesis in the elderly.

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5465-5470

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scholarly article

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10.1073/PNAS.1000834107

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12

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107

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Mikael Sigvardsson

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2010-03-18T00:00:00Z

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42371753

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20304793

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2851806

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