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Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesisSilent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-riboseThe structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylationNADPH-generating systems in bacteria and archaeaIdentification, characterization, and crystal structure of Bacillus subtilis nicotinic acid mononucleotide adenylyltransferaseStructure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurinCrystal structure of human nicotinamide mononucleotide adenylyltransferase in complex with NMNStructural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesisA phosphoenzyme mimic, overlapping catalytic sites and reaction coordinate motion for human NAMPTStructure and reaction mechanism of human nicotinamide phosphoribosyltransferaseEukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase.Mono(ADP-ribosyl)ation of 2'-deoxyguanosine residue in DNA by an apoptosis-inducing protein, pierisin-1, from cabbage butterflyAccumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient miceCrystal structure of the NAD biosynthetic enzyme quinolinate synthase.Gentamicin rapidly inhibits mitochondrial metabolism in high-frequency cochlear outer hair cells.NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents.The reported human NADsyn2 is ammonia-dependent NAD synthetase from a pseudomonad.Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NADIncreased plasma nicotinamide phosphoribosyltransferase is associated with a hyperproliferative phenotype and restrains disease progression in MPN-associated myelofibrosis.Rapid evolution of PARP genes suggests a broad role for ADP-ribosylation in host-virus conflicts.Characterization of NAD uptake in mammalian cells.MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase.Cyclic ADP ribose as a calcium-mobilizing messenger.Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase.Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents.Nicotinamide mononucleotide adenylyltransferase displays alternate binding modes for nicotinamide nucleotidesStructure and function of NAD kinase and NADP phosphatase: key enzymes that regulate the intracellular balance of NAD(H) and NADP(H).Poly(ADP-ribosyl)ation polymerases: mechanism and new target of anticancer therapy.Mitochondrial dysfunction and nicotinamide dinucleotide catabolism as mechanisms of cell death and promising targets for neuroprotection.MICAL, the flavoenzyme participating in cytoskeleton dynamicsMolecular, biochemical, and functional characterization of a Nudix hydrolase protein that stimulates the activity of a nicotinoprotein alcohol dehydrogenase.Expression and function of visfatin (Nampt), an adipokine-enzyme involved in inflammatory pathways of osteoarthritis.Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is a tumoural cytokine released from melanoma.Transformation and action of extracellular NAD+ in perfused rat and mouse livers.Extracellular ATP induces CD44 shedding from macrophage-like P388D1 cells via the P2X7 receptor.Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway.Identification and characterization of VopT, a novel ADP-ribosyltransferase effector protein secreted via the Vibrio parahaemolyticus type III secretion system 2.Crystal structure of human nicotinic acid phosphoribosyltransferase.Effects of NAD at purine receptors in isolated blood vessels.
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description
im März 2000 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в березні 2000
@uk
name
New functions of a long-known molecule
@en
New functions of a long-known molecule
@nl
type
label
New functions of a long-known molecule
@en
New functions of a long-known molecule
@nl
prefLabel
New functions of a long-known molecule
@en
New functions of a long-known molecule
@nl
P2860
P1433
P1476
New functions of a long-known molecule
@en
P2860
P304
P356
10.1046/J.1432-1327.2000.01187.X
P407
P577
2000-03-01T00:00:00Z