about
The OtsAB pathway is essential for trehalose biosynthesis in Mycobacterium tuberculosisHost genetics in granuloma formation: human-like lung pathology in mice with reciprocal genetic susceptibility to M. tuberculosis and M. avium.Neutrophil responses to Mycobacterium tuberculosis infection in genetically susceptible and resistant miceMutants of Mycobacterium tuberculosis lacking three of the five rpf-like genes are defective for growth in vivo and for resuscitation in vitro.A new technique for obtaining whole pathogen transcriptomes from infected host tissues.Analysis of cellular phenotypes that mediate genetic resistance to tuberculosis using a radiation bone marrow chimera approachCapacity of lung stroma to educate dendritic cells inhibiting mycobacteria-specific T-cell response depends upon genetic susceptibility to tuberculosis.RNA-Seq analysis of Mycobacterium avium non-coding transcriptomeThe QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.Man and mouse TB: contradictions and solutions.Latent tuberculosis infection: what we know about its genetic control?Analysis of the lung transcriptome in Mycobacterium tuberculosis-infected mice reveals major differences in immune response pathways between TB-susceptible and resistant hosts.Overexpression of Adenylyl Cyclase Encoded by the Mycobacterium tuberculosis Rv2212 Gene Confers Improved Fitness, Accelerated Recovery from Dormancy and Enhanced Virulence in Mice.Host genetics in susceptibility to and severity of mycobacterial diseases.Local targeting NF-κB in the lung tissue of TB-infected mice diminishes the level of pathology.B-lymphocytes forming follicle-like structures in the lung tissue of tuberculosis-infected mice: Dynamics, phenotypes and functional activity.A new coding mutation in the Tnf-alpha leader sequence in tuberculosis-sensitive I/St mice causes higher secretion levels of soluble TNF-alpha.Therapeutic Effect of Recombinant Mutated Interleukin 11 in the Mouse Model of Tuberculosis.In Vitro Activity of 3-Triazeneindoles against Mycobacterium tuberculosis and Mycobacterium avium.Neutrophils exacerbate tuberculosis infection in genetically susceptible mice.Formation of compact aggregates of B-lymphocytes in lung tissue during mycobacterial infection in mice depends on TNF production by these cells and is not an element of the host's immunological protection.Reactivation of dormant "non-culturable" Mycobacterium tuberculosis developed in vitro after injection in mice: both the dormancy depth and host genetics influence the outcome.Constitutive differences in gene expression profiles parallel genetic patterns of susceptibility to tuberculosis in mice.Mycobacterium tuberculosis attenuated by multiple deletions of rpf genes effectively protects mice against TB infection.Influence of the mouse Bcg, Tbc-1 and xid genes on resistance and immune responses to tuberculosis infection and efficacy of bacille Calmette-Guérin (BCG) vaccination.Specificity and efficacy of dendritic cell-based vaccination against tuberculosis with complex mycobacterial antigens in a mouse model.Lung cell responses to M. tuberculosis in genetically susceptible and resistant mice following intratracheal challenge.Comparative analysis of T lymphocytes recovered from the lungs of mice genetically susceptible, resistant, and hyperresistant to Mycobacterium tuberculosis-triggered disease.Genetic markers in the Tuvan population of Todja, SiberiaComparative Analysis of Different Vaccine Constructs Expressing Defined Antigens fromMycobacterium tuberculosisDeletion of the 19kDa antigen does not alter the protective efficacy of BCGSeverity of tuberculosis in mice is linked to distal chromosome 3 and proximal chromosome 9The 19-kD antigen and protective immunity in a murine model of tuberculosisCharacterization of T cell clones derived from lymph nodes and lungs of Pseudomonas aeruginosa-susceptible and resistant mice following immunization with heat-killed bacteriaIntranasal BCG vaccination protects BALB/c mice against virulent Mycobacterium bovis and accelerates production of IFN-gamma in their lungsAntimycobacterial activity of bacteriocins and their complexes with liposomesCD4 T cells producing IFN-gamma in the lungs of mice challenged with mycobacteria express a CD27-negative phenotypeMycobacterial dissemination and cellular responses after 1-lobe restricted tuberculosis infection of genetically susceptible and resistant miceDirect comparison of low-dose and Cornell-like models of chronic and reactivation tuberculosis in genetically susceptible I/St and resistant B6 miceH2 complex controls CD4/CD8 ratio, recurrent responsiveness to repeated stimulations, and resistance to activation-induced apoptosis during T cell response to mycobacterial antigens
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P50
description
researcher ORCID ID = 0000-0002-3683-3085
@en
wetenschapper
@nl
name
Alexander Apt
@en
Alexander S Apt
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Alexander S Apt
@es
Alexander S Apt
@nl
Alexander Solomonowitsch Apt
@de
Александр Соломонович Апт
@ru
type
label
Alexander Apt
@en
Alexander S Apt
@ast
Alexander S Apt
@es
Alexander S Apt
@nl
Alexander Solomonowitsch Apt
@de
Александр Соломонович Апт
@ru
altLabel
Aleksandr Apt
@en
Aleksandr Solomonovich Apt
@en
Alexander Apt
@de
Alexander S Apt
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prefLabel
Alexander Apt
@en
Alexander S Apt
@ast
Alexander S Apt
@es
Alexander S Apt
@nl
Alexander Solomonowitsch Apt
@de
Александр Соломонович Апт
@ru
P106
P1153
7006958166
P21
P31
P496
0000-0002-3683-3085