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General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADHStructural, functional, and spectroscopic characterization of the substrate scope of the novel nitrating cytochrome P450 TxtE.Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases.A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases.Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation.Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan SynthaseA Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation.Artificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases.Enzyme Nicotinamide Cofactor Specificity Reversal Guided by Automated Structural Analysis and Library Design.Enantioselective, intermolecular benzylic C-H amination catalysed by an engineered iron-haem enzyme.Engineered Biosynthesis of β-Alkyl Tryptophan AnaloguesEngineered Biosynthesis of β-Alkyl Tryptophan Analogues
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description
researcher ORCID ID = 0000-0002-5419-4192
@en
wetenschapper
@nl
name
Sabine Brinkmann-Chen
@ast
Sabine Brinkmann-Chen
@en
Sabine Brinkmann-Chen
@es
Sabine Brinkmann-Chen
@nl
type
label
Sabine Brinkmann-Chen
@ast
Sabine Brinkmann-Chen
@en
Sabine Brinkmann-Chen
@es
Sabine Brinkmann-Chen
@nl
prefLabel
Sabine Brinkmann-Chen
@ast
Sabine Brinkmann-Chen
@en
Sabine Brinkmann-Chen
@es
Sabine Brinkmann-Chen
@nl
P31
P496
0000-0002-5419-4192