PRC2
PRC2 (polycomb repressive complex 2) is one of the two classes of polycomb-group proteins or (PcG). The other component of this group of proteins is PRC1 (Polycomb Repressive Complex 1). This complex has histone methyltransferase activity and primarily methylates histone H3 on lysine 27 (i.e. H3K27me3), a mark of transcriptionally silent chromatin. PRC2 is required for initial targeting of genomic region (PRC Response Elements or PRE) to be silenced, while PRC1 is required for stabilizing this silencing and underlies cellular memory of silenced region after cellular differentiation. PRC1 also mono-ubiquitinates histone H2A on lysine 119 (H2AK119Ub1). These proteins are required for long term epigenetic silencing of chromatin and have an important role in stem cell differentiation and early
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AEBP2Acute megakaryoblastic leukemiaAnne Schaefer (scientist)Antisense RNACDKN2BASCellular differentiationCohen-Gibson syndromeEZH2Epigenetics of human developmentEpigenetics of plant growth and developmentEzh2 geneFollicular lymphomaGATA1GNAS complex locusH3K27me3HOTAIRHSV epigeneticsHeterochromatinIn situ lymphoid neoplasiaJoomyeong KimJun dimerization proteinKCNQ1OT1MBD3Mdm2O-GlcNAcPDGFRAPPP1R8PRC (disambiguation)Polycomb-group proteinsPolycomb repressive complex 1Polycomb repressive complex 2SKIDA1SUZ12S phaseSex chromosomeTranscriptional regulationTransient myeloproliferative diseaseTudor domainWeaver syndromeX-inactivation
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PRC2
PRC2 (polycomb repressive complex 2) is one of the two classes of polycomb-group proteins or (PcG). The other component of this group of proteins is PRC1 (Polycomb Repressive Complex 1). This complex has histone methyltransferase activity and primarily methylates histone H3 on lysine 27 (i.e. H3K27me3), a mark of transcriptionally silent chromatin. PRC2 is required for initial targeting of genomic region (PRC Response Elements or PRE) to be silenced, while PRC1 is required for stabilizing this silencing and underlies cellular memory of silenced region after cellular differentiation. PRC1 also mono-ubiquitinates histone H2A on lysine 119 (H2AK119Ub1). These proteins are required for long term epigenetic silencing of chromatin and have an important role in stem cell differentiation and early
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PRC2 (polycomb repressive comp ...... s, insects, fungi, and plants.
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PRC2 (polycomb repressive comp ...... cell differentiation and early
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PRC2
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