Tumor hypoxia
Tumor hypoxia is the situation where tumor cells have been deprived of oxygen. As a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues. Hypoxic microenvironements in solid tumors are a result of available oxygen being consumed within 70 to 150 μm of tumour vasculature by rapidly proliferating tumor cells thus limiting the amount of oxygen available to diffuse further into the tumor tissue. In order to support continuous growth and proliferation in challenging hypoxic environments, cancer cells are found to alter their metabolism. Furthermore, hypoxia is known to change cell behavior and is associated with extracellular matrix remodeling and increased migratory and metast
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Benign tumorC-1027ChemotherapyCrocetinDDIT4DEPT (medicine)David GorskiEndothelin 2Epithelioid sarcomaEribulinEvofosfamideFast neutron therapyFlavin reductaseHost response to cancer therapy1,2-dimethoxyethaanHypoxiaHypoxia-activated prodrugHypoxic tumorJacques PouysségurLouis Harold GrayOxygen effect1,2-dimethoxyethaanPKM2PR-104Pancreatic cancerProstate cancerPyruvate dehydrogenase kinaseSodium MRITargeted drug deliveryThymidine phosphorylaseTirapazamineTumour hypoxia
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Tumor hypoxia
Tumor hypoxia is the situation where tumor cells have been deprived of oxygen. As a tumor grows, it rapidly outgrows its blood supply, leaving portions of the tumor with regions where the oxygen concentration is significantly lower than in healthy tissues. Hypoxic microenvironements in solid tumors are a result of available oxygen being consumed within 70 to 150 μm of tumour vasculature by rapidly proliferating tumor cells thus limiting the amount of oxygen available to diffuse further into the tumor tissue. In order to support continuous growth and proliferation in challenging hypoxic environments, cancer cells are found to alter their metabolism. Furthermore, hypoxia is known to change cell behavior and is associated with extracellular matrix remodeling and increased migratory and metast
has abstract
La hipoxia tumoral es un trast ...... ento migratorio y metastásico.
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Tumor hypoxia is the situation ...... atory and metastatic behavior.
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1,024,127,851
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forward enzyme
Expression up-regulated by HIF-1
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Hexokinase Expression up-regulated by HIF-1
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Phosphoglucose isomerase Expression up-regulated by HIF-1
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major product
(D)-glyceraldehyde 3-phosphate
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major substrate
β-(D)-Fructose 1,6-bisphosphate
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PO
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H2O
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product
(D)-1,3-bisphosphoglycerate
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α-(D)-Glucose 6-phosphate
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β-(D)-Fructose 1,6-bisphosphate
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β-(D)-Fructose 6-phosphate
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forward
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reversible
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reverse enzyme
substrate
(D)-Glucose
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α-(D)-Glucose 6-phosphate
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β-(D)-Fructose 6-phosphate
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hypernym
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La hipoxia tumoral es un trast ...... simismo, se sabe que la hipoxi
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Tumor hypoxia is the situation ...... increased migratory and metast
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label
Hipoxia tumoral
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Tumor hypoxia
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