about
P688
Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegansHuman INT6/eIF3e is required for nonsense-mediated mRNA decayThe human RNA surveillance factor UPF1 is required for S phase progression and genome stabilityMammalian orthologues of a yeast regulator of nonsense transcript stabilityRegulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleusNMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNAFunctions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translationHuman UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replicationThe surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAsCloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 proteinRegnase-1 and Roquin regulate inflammatory mRNAsTelomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome endsPlakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteinsMOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
P921
description
humanes Protein
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
protein
@id
protein
@sv
proteinë
@sq
protèin
@ace
protéine humaine
@fr
بروتين بشري
@ar
name
UPF1 RNA helicase and ATPase
@en
UPF1 RNA helicase and ATPase
@nl
type
label
UPF1 RNA helicase and ATPase
@en
UPF1 RNA helicase and ATPase
@nl
altLabel
ATP-dependent helicase RENT1
@en
NORF1
@en
UPF1 regulator of nonsense transcripts homolog
@en
UPF1
@en
delta helicase
@en
hUpf1
@en
nonsense mRNA reducing factor 1
@en
regulator of nonsense transcripts 1
@en
smg-2 homolog, nonsense mediated mRNA decay factor
@en
up-frameshift mutation 1 homolog
@en
prefLabel
UPF1 RNA helicase and ATPase
@en
UPF1 RNA helicase and ATPase
@nl
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NP_001284478
XP_016882594
XP_016882595
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ENSP00000262803
ENSP00000470142