The human RNA surveillance factor UPF1 is required for S phase progression and genome stability
about
DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegansAffinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotranspositionA quantitative telomeric chromatin isolation protocol identifies different telomeric statesHuman UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replicationSMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decayTIN2-tethered TPP1 recruits human telomerase to telomeres in vivoTERRA: telomeric repeat-containing RNAMechanism and regulation of the nonsense-mediated decay pathwaySaccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome endsProtein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomeraseFunctions of the nonsense-mediated mRNA decay pathway in Drosophila developmentUPF2 is a critical regulator of liver development, function and regenerationHIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activitiesNonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.Function and pathological implications of exon junction complex factor Y14A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability.FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling.Telomeric RNAs as a novel player in telomeric integrityThe exon junction complex component Magoh controls brain size by regulating neural stem cell division.Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombeNonsense-mediated decay factors are involved in the regulation of selenoprotein mRNA levels during selenium deficiencyTRPC1 transcript variants, inefficient nonsense-mediated decay and low up-frameshift-1 in vascular smooth muscle cells.Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways.Functional characterization of the TERRA transcriptome at damaged telomeres.Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent mannerUnexpected roles for UPF1 in HIV-1 RNA metabolism and translation.RNA homeostasis governed by cell type-specific and branched feedback loops acting on NMD.DNA structure-specific priming of ATR activation by DNA-PKcsDhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish.UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome.Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question.The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA.Cotranscriptional effect of a premature termination codon revealed by live-cell imaging.Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export.N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMDMechanistic insights and identification of two novel factors in the C. elegans NMD pathway.The abundance of RNPS1, a protein component of the exon junction complex, can determine the variability in efficiency of the Nonsense Mediated Decay pathway
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The human RNA surveillance factor UPF1 is required for S phase progression and genome stability
description
2006 nî lūn-bûn
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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2006 թվականի փետրվարին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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The human RNA surveillance fac ...... ogression and genome stability
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The human RNA surveillance fac ...... ogression and genome stability
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The human RNA surveillance fac ...... ogression and genome stability
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The human RNA surveillance fac ...... ogression and genome stability
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The human RNA surveillance fac ...... ogression and genome stability
@ast
The human RNA surveillance fac ...... ogression and genome stability
@en
The human RNA surveillance fac ...... ogression and genome stability
@en-gb
The human RNA surveillance fac ...... ogression and genome stability
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The human RNA surveillance fac ...... ogression and genome stability
@ast
The human RNA surveillance fac ...... ogression and genome stability
@en
The human RNA surveillance fac ...... ogression and genome stability
@en-gb
The human RNA surveillance fac ...... ogression and genome stability
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The human RNA surveillance fac ...... ogression and genome stability
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10.1016/J.CUB.2006.01.018
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2006-02-21T00:00:00Z