Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication
about
The THO complex component Thp2 counteracts telomeric R-loops and telomere shorteningA three-state model for the regulation of telomerase by TERRA and hnRNPA1TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome endsPlakophilin-associated RNA-binding proteins in prostate cancer and their implications in tumor progression and metastasis.HIV-1 Recruits UPF1 but Excludes UPF2 to Promote Nucleocytoplasmic Export of the Genomic RNA.Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activitiesNonsense-mediated decay factors are involved in the regulation of selenoprotein mRNA levels during selenium deficiencyTelomerase efficiently elongates highly transcribing telomeres in human cancer cells.RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells.Functional characterization of the TERRA transcriptome at damaged telomeres.Telomere-regulating genes and the telomere interactome in familial cancers.Flap Endonuclease 1 Limits Telomere Fragility on the Leading StrandHuman telomeres replicate using chromosome-specific, rather than universal, replication programs.A three-state model of telomere control over human proliferative boundaries.Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains.TERRA, hnRNP A1, and DNA-PKcs Interactions at Human Telomeres.Replication of telomeres and the regulation of telomerase.DNA repair at telomeres: keeping the ends intact.UPF1 is crucial for the infectivity of human immunodeficiency virus type 1 progeny virions.Telomeres and disease: enter TERRA.UPF1 involvement in nuclear functions.Telomere shortening and Alzheimer's disease.Regulation of natural mRNAs by the nonsense-mediated mRNA decay pathway.Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs.DNA substrate recognition and processing by the full-length human UPF1 helicase.Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion.Solving the Telomere Replication Problem.DNA Replication Origins and Fork Progression at Mammalian Telomeresp53 downregulates the Fanconi anaemia DNA repair pathway.Regulation of telomere metabolism by the RNA processing protein Xrn1.RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent.Conservation of Nonsense-Mediated mRNA Decay Complex Components Throughout Eukaryotic Evolution.Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition.Telomeric Repeat-Containing RNAs (TERRA) Decrease in Squamous Cell Carcinoma of the Head and Neck Is Associated with Worsened Clinical Outcome.Nonsense-mediated mRNA decay: a 'nonsense' pathway makes sense in stem cell biology.The RNA surveillance proteins UPF1, UPF2 and SMG6 affect HIV-1 reactivation at a post-transcriptional level.
P2860
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P248
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P2860
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
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2011年學術文章
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name
Human UPF1 interacts with TPP1 ...... ere leading-strand replication
@ast
Human UPF1 interacts with TPP1 ...... ere leading-strand replication
@en
Human UPF1 interacts with TPP1 ...... ere leading-strand replication
@en-gb
Human UPF1 interacts with TPP1 ...... ere leading-strand replication
@nl
type
label
Human UPF1 interacts with TPP1 ...... ere leading-strand replication
@ast
Human UPF1 interacts with TPP1 ...... ere leading-strand replication
@en
Human UPF1 interacts with TPP1 ...... ere leading-strand replication
@en-gb
Human UPF1 interacts with TPP1 ...... ere leading-strand replication
@nl
prefLabel
Human UPF1 interacts with TPP1 ...... ere leading-strand replication
@ast
Human UPF1 interacts with TPP1 ...... ere leading-strand replication
@en
Human UPF1 interacts with TPP1 ...... ere leading-strand replication
@en-gb
Human UPF1 interacts with TPP1 ...... ere leading-strand replication
@nl
P2093
P2860
P50
P921
P3181
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P1476
Human UPF1 interacts with TPP1 ...... ere leading-strand replication
@en
P2093
Christina Raftopoulou
Harry Wischnewski
Sophie Redon
P2860
P304
P3181
P356
10.1038/EMBOJ.2011.280
P407
P577
2011-10-05T00:00:00Z