Identification of small molecule activators of cryptochrome - Wikidata - awgldk - TriplyDB

Identification of small molecule activators of cryptochrome

Identification of small molecule activators of cryptochrome

http://www.wikidata.org/entity/Q34288305

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Cancer Clocks Out for Lunch: Disruption of Circadian Rhythm and Metabolic Oscillation in Cancer Clock genes in hypertension: novel insights from rodent models Circadian clock control of endocrine factors Chronopharmacology: new insights and therapeutic implications SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase Chemical chronobiology: Toward drugs manipulating time.Coupling circadian rhythms of metabolism and chromatin remodelling Manipulating the circadian and sleep cycles to protect against metabolic disease Adipose Clocks: Burning the Midnight Oil Emerging models for the molecular basis of mammalian circadian timing Clock genes, pancreatic function, and diabetes The CRTC1-SIK1 pathway regulates entrainment of the circadian clock Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour Circadian pacemaking in cells and circuits of the suprachiasmatic nucleus.Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour Systems Chronotherapeutics A Cryptochrome 2 mutation yields advanced sleep phase in humans ATP binding turns plant cryptochrome into an efficient natural photoswitch Mechanism of the circadian clock in physiology.Nuclear receptors rock around the clock Small molecule modifiers of circadian clocks.The PXDLS linear motif regulates circadian rhythmicity through protein-protein interactions Circadian Clocks in Articular Cartilage and Bone: A Compass in the Sea of Matrices.Systems Biology-Derived Discoveries of Intrinsic Clocks.Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder.Target identification for small bioactive molecules: finding the needle in the haystack.Target identification and mechanism of action in chemical biology and drug discovery.Amplitude metrics for cellular circadian bioluminescence reporters.An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.Estimating confidence intervals in predicted responses for oscillatory biological models CRY2 genetic variants associate with dysthymia.The hepatic circadian clock modulates xenobiotic metabolism in mice.DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization Membrane-Targeting DCAP Analogues with Broad-Spectrum Antibiotic Activity against Pathogenic Bacteria C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock.Elucidating Compound Mechanism of Action by Network Perturbation Analysis.Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription.Quantifying Stochastic Noise in Cultured Circadian Reporter Cells.

P2860

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P2860

Identification of small molecule activators of cryptochrome

http://www.wikidata.org/entity/Q34288305

description

2012 nî lūn-bûn

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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի հուլիսին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

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name

Identification of small molecule activators of cryptochrome

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Identification of small molecule activators of cryptochrome

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Identification of small molecule activators of cryptochrome

@nl

type

label

Identification of small molecule activators of cryptochrome

@ast

Identification of small molecule activators of cryptochrome

@en

Identification of small molecule activators of cryptochrome

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prefLabel

Identification of small molecule activators of cryptochrome

@ast

Identification of small molecule activators of cryptochrome

@en

Identification of small molecule activators of cryptochrome

@nl

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SCIENCE.1223710

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P1476

Identification of small molecule activators of cryptochrome

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P2093

David K Welsh

http://www.w3.org/2001/XMLSchema#string

Jae Wook Lee

http://www.w3.org/2001/XMLSchema#string

Keiko Iwaisako

http://www.w3.org/2001/XMLSchema#string

Mariko Sawa

http://www.w3.org/2001/XMLSchema#string

Pagkapol Y Pongsawakul

http://www.w3.org/2001/XMLSchema#string

Peter C St John

http://www.w3.org/2001/XMLSchema#string

Peter G Schultz

http://www.w3.org/2001/XMLSchema#string

Steve A Kay

http://www.w3.org/2001/XMLSchema#string

Takako Noguchi

http://www.w3.org/2001/XMLSchema#string

Tim Sonntag

http://www.w3.org/2001/XMLSchema#string

P2860

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein

A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo

PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues.

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

A genome-wide RNAi screen for modifiers of the circadian clock in human cells

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1094-1097

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scholarly article

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10.1126/SCIENCE.1223710

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6098

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337

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Francis J. Doyle III

David A. Brenner

Tsuyoshi Hirota

P577

2012-07-12T00:00:00Z

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229153599

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22798407

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3589997

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