Identification of small molecule activators of cryptochrome
about
Cancer Clocks Out for Lunch: Disruption of Circadian Rhythm and Metabolic Oscillation in CancerClock genes in hypertension: novel insights from rodent modelsCircadian clock control of endocrine factorsChronopharmacology: new insights and therapeutic implicationsSCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocketCrystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligaseChemical chronobiology: Toward drugs manipulating time.Coupling circadian rhythms of metabolism and chromatin remodellingManipulating the circadian and sleep cycles to protect against metabolic diseaseAdipose Clocks: Burning the Midnight OilEmerging models for the molecular basis of mammalian circadian timingClock genes, pancreatic function, and diabetesThe CRTC1-SIK1 pathway regulates entrainment of the circadian clockDistinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviourCircadian pacemaking in cells and circuits of the suprachiasmatic nucleus.Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviourSystems ChronotherapeuticsA Cryptochrome 2 mutation yields advanced sleep phase in humansATP binding turns plant cryptochrome into an efficient natural photoswitchMechanism of the circadian clock in physiology.Nuclear receptors rock around the clockSmall molecule modifiers of circadian clocks.The PXDLS linear motif regulates circadian rhythmicity through protein-protein interactionsCircadian Clocks in Articular Cartilage and Bone: A Compass in the Sea of Matrices.Systems Biology-Derived Discoveries of Intrinsic Clocks.Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder.Target identification for small bioactive molecules: finding the needle in the haystack.Target identification and mechanism of action in chemical biology and drug discovery.Amplitude metrics for cellular circadian bioluminescence reporters.An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.Estimating confidence intervals in predicted responses for oscillatory biological modelsCRY2 genetic variants associate with dysthymia.The hepatic circadian clock modulates xenobiotic metabolism in mice.DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilizationMembrane-Targeting DCAP Analogues with Broad-Spectrum Antibiotic Activity against Pathogenic BacteriaC-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock.Elucidating Compound Mechanism of Action by Network Perturbation Analysis.Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription.Quantifying Stochastic Noise in Cultured Circadian Reporter Cells.
P2860
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P2860
Identification of small molecule activators of cryptochrome
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Identification of small molecule activators of cryptochrome
@ast
Identification of small molecule activators of cryptochrome
@en
Identification of small molecule activators of cryptochrome
@nl
type
label
Identification of small molecule activators of cryptochrome
@ast
Identification of small molecule activators of cryptochrome
@en
Identification of small molecule activators of cryptochrome
@nl
prefLabel
Identification of small molecule activators of cryptochrome
@ast
Identification of small molecule activators of cryptochrome
@en
Identification of small molecule activators of cryptochrome
@nl
P2093
P2860
P50
P356
P1433
P1476
Identification of small molecule activators of cryptochrome
@en
P2093
David K Welsh
Jae Wook Lee
Keiko Iwaisako
Mariko Sawa
Pagkapol Y Pongsawakul
Peter C St John
Peter G Schultz
Steve A Kay
Takako Noguchi
Tim Sonntag
P2860
P304
P356
10.1126/SCIENCE.1223710
P407
P577
2012-07-12T00:00:00Z