about
P688
Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transductionNormal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor moleculeLDL receptor-related protein as a component of the midkine receptorAn endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteinsAquaporin-4 is expressed in basolateral membranes of proximal tubule S3 segments in mouse kidneyThe inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting systemInteraction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11Arf4 is required for Mammalian development but dispensable for ciliary assemblyExpression and role of cubilin in the internalization of nutrients during the peri-implantation development of the rodent embryoLRP2/megalin is required for patterning of the ventral telencephalonMouse amnionless, which is required for primitive streak assembly, mediates cell-surface localization and endocytic function of cubilin on visceral endoderm and kidney proximal tubulesLoss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubulesCellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2.Role of endocytosis in cellular uptake of sex steroids.Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells.Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development.Megalin-mediated endocytosis of cystatin C in proximal tubule cells.Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M.Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss.Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin.LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development.LRP2 mediates folate uptake in the developing neural tube.Megalin interacts with APP and the intracellular adapter protein FE65 in neurons.Megalin mediates the transport of leptin across the blood-CSF barrier.
P921
Q22254170-D45108DE-B080-4705-8041-AF1A62EF6181Q24336718-5D3AAFD3-601B-474C-910B-26A23FE5A3C1Q24338117-3BB1701A-DC21-4DD9-87D9-6D731A676D4FQ28142429-619AE3CF-FE2D-4EB6-AB93-B2910467DA48Q28370564-9D4045BF-079E-48EA-9C50-54A9A23C3B44Q28505461-82846206-B0DD-4C01-B3C1-0D29D5FED2FBQ28507979-A8D2AF89-A072-4CC3-AD26-64F3C78D4209Q28508029-92A1B5A9-2934-4F86-9986-5DE60AE9372FQ28509728-0C1BE007-C936-4781-A401-D200F4725C9BQ28509831-991FC67A-4449-4405-A834-224692E4BDD3Q28511408-D826D3B1-50F8-43E2-9CF1-FE188E500BA9Q28511442-1BC328DC-3B49-4823-B0DE-FF8C685A1C0FQ28590680-FBDAE04A-CA17-4B8A-A5B4-E5188281BF7EQ28592336-42B7F63D-2A81-41D3-915C-BEF59489108FQ33849227-597F7C1E-DFE6-4171-8F22-481ACA3EDAE9Q34448507-17E945E8-125B-493F-BBE5-AF3864C2FFE2Q34655573-53D5E099-5B56-4E8A-9480-8B6B7BC04FEAQ36856002-A981EB5C-61C5-4F29-8A30-5C541F87EAD8Q40036143-2FEC6EDD-FACC-4CDD-833D-AAD3B667EE9EQ40036165-2F271A06-94D4-47F4-9488-DEB5E40A2978Q40036195-AAED3B57-6661-4383-9AEE-9714D37E6CBFQ40036211-1BE67D53-1970-4060-AC0D-FB42C2D1E3AFQ40036232-F32FAB0C-F351-44F1-9A00-4E2B3970DB86Q40036246-C7209162-D48C-4AFC-A969-F3AF398F36F4Q40036313-74E48F24-E886-48A5-8F58-CA2FF8B0508AQ40036337-8F53685E-D4A6-475A-9A99-12189FDCEAE8Q41166605-559FE3B7-D3E7-4B2D-9359-F656E068DD44
P921
description
mammalian protein found in Mus musculus
@en
protein
@id
proteinë
@sq
proteïne in Low density lipoprotein receptor-related protein 2
@nl
protèin
@ace
بروتين في فأر المنازل
@ar
name
Low density lipoprotein receptor-related protein 2
@en
Low density lipoprotein receptor-related protein 2
@nl
type
label
Low density lipoprotein receptor-related protein 2
@en
Low density lipoprotein receptor-related protein 2
@nl
altLabel
LRP-2
@en
Lrp2
@en
Megalin
@en
glycoprotein 330
@en
gp330
@en
low-density lipoprotein receptor-related protein 2
@en
prefLabel
Low density lipoprotein receptor-related protein 2
@en
Low density lipoprotein receptor-related protein 2
@nl
P361
P527
P680
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P705
P352
P637
P31
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P527
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NP_001074557
P680
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P702
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ENSMUSP00000079752
ENSMUSP00000090212
ENSMUSP00000097628
P7260
9.B.87.1.1