Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
about
Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammalsExpression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint controlNuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressorBRCA2 and homologous recombinationCDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repairBRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damageAPRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancerBRCA2 suppresses cell proliferation via stabilizing MAGE-D1The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombinationHighlight: BRCA1 and BRCA2 proteins in breast cancerInteractions between human BRCA2 protein and the meiosis-specific recombinase DMC1RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylationPALB2 is an integral component of the BRCA complex required for homologous recombination repairN terminus of CtIP is critical for homologous recombination-mediated double-strand break repairIdentification of a novel human Rad51 variant that promotes DNA strand exchangePALB2 regulates recombinational repair through chromatin association and oligomerizationSOSS complexes participate in the maintenance of genomic stabilityFission yeast rad51 and dmc1, two efficient DNA recombinases forming helical nucleoprotein filamentsConstitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation.hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damageThe Rad51 paralog Rad51B promotes homologous recombinational repairBRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation siteThe BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repairFunctional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stressChk2 phosphorylation of BRCA1 regulates DNA double-strand break repairStabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility proteinBASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structuresSusceptibility pathways in Fanconi's anemia and breast cancerDirect DNA binding by Brca1Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joiningComplex formation by the human RAD51C and XRCC3 recombination repair proteinsCaretaker Brca1: keeping the genome in the straight and narrow.XRCC2 is Required for the Formation of Rad51 Foci Induced by Ionizing Radiation and DNA Cross-Linking Agent Mitomycin CBRCA1 Zinc RING Finger Domain Disruption Alters Caspase Response in Ovarian Surface Epithelial Cells.Role of BRCA gene dysfunction in breast and ovarian cancer predisposition.Distinct functions of BRCA1 and BRCA2 in double-strand break repairRepair of strand breaks by homologous recombinationAssembly of RecA-like recombinases: distinct roles for mediator proteins in mitosis and meiosisHomologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsThe SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradation
P2860
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P248
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P2860
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
description
1998 nî lūn-bûn
@nan
1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Stable interaction between the ...... s in mitotic and meiotic cells
@ast
Stable interaction between the ...... s in mitotic and meiotic cells
@en
Stable interaction between the ...... s in mitotic and meiotic cells
@en-gb
Stable interaction between the ...... s in mitotic and meiotic cells
@nl
type
label
Stable interaction between the ...... s in mitotic and meiotic cells
@ast
Stable interaction between the ...... s in mitotic and meiotic cells
@en
Stable interaction between the ...... s in mitotic and meiotic cells
@en-gb
Stable interaction between the ...... s in mitotic and meiotic cells
@nl
prefLabel
Stable interaction between the ...... s in mitotic and meiotic cells
@ast
Stable interaction between the ...... s in mitotic and meiotic cells
@en
Stable interaction between the ...... s in mitotic and meiotic cells
@en-gb
Stable interaction between the ...... s in mitotic and meiotic cells
@nl
P2093
P921
P3181
P1433
P1476
Stable interaction between the ...... s in mitotic and meiotic cells
@en
P2093
A F Gazdar
D M Livingston
D P Silver
G Tomlinson
S B Cantor
P304
P3181
P356
10.1016/S1097-2765(00)80276-2
P407
P577
1998-09-01T00:00:00Z