BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage
about
Deubiquitylating enzymes and diseaseThe proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break responseUbiquitination and deubiquitination of NP protein regulates influenza A virus RNA replicationBRCA2 suppresses cell proliferation via stabilizing MAGE-D1MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaksSuppression of cancer cell growth by promoting cyclin D1 degradationEvidence for distinct functions for human DNA repair factors hHR23A and hHR23BUbiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressorRegulation and cellular roles of ubiquitin-specific deubiquitinating enzymesWriters, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break RepairRole of Deubiquitinating Enzymes in DNA RepairStructure and Catalytic Regulatory Function of Ubiquitin Specific Protease 11 N-Terminal and Ubiquitin-like DomainsSolution structure of the human ubiquitin-specific protease 15 DUSP domainEvolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11Differences in regulation of tight junctions and cell morphology between VHL mutations from disease subtypes.Sensitivity to poly(ADP-ribose) polymerase (PARP) inhibition identifies ubiquitin-specific peptidase 11 (USP11) as a regulator of DNA double-strand break repair.The regulation of TGF-β/SMAD signaling by protein deubiquitination.Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.USP11 regulates p53 stability by deubiquitinating p53.Skp2 overexpression is associated with loss of BRCA2 protein in human prostate cancer.Ubiquitin-specific proteases as therapeutic targets for the treatment of breast cancerDeubiquitinases in cancer.DNA damage repair is unaffected by mimicked heterozygous levels of BRCA2 in HT-29 cells.USP11 augments TGFβ signalling by deubiquitylating ALK5.Homologous recombination and its regulationUbiquitin pathway and ovarian cancer.Targeting the ubiquitin-proteasome pathway in breast cancer therapy.USP-11 as a predictive and prognostic factor following neoadjuvant therapy in women with breast cancerOrtholog of BRCA2-interacting protein BCCIP controls morphogenetic responses during DNA replication stress in Ustilago maydis.Protein partners of deubiquitinating enzymes.RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis.USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha.The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention.The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeuticsThe ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 1: post-translational regulation.Regulation of XIAP Turnover Reveals a Role for USP11 in Promotion of Tumorigenesis.DNA damage emergency: cellular garbage disposal to the rescue?Deubiquitylating enzymes and DNA damage response pathways.Cell death and deubiquitinases: perspectives in cancer.
P2860
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P2860
BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
BRCA2 is ubiquitinated in vivo ...... ellular response to DNA damage
@ast
BRCA2 is ubiquitinated in vivo ...... ellular response to DNA damage
@en
BRCA2 is ubiquitinated in vivo ...... ellular response to DNA damage
@en-gb
BRCA2 is ubiquitinated in vivo ...... ellular response to DNA damage
@nl
type
label
BRCA2 is ubiquitinated in vivo ...... ellular response to DNA damage
@ast
BRCA2 is ubiquitinated in vivo ...... ellular response to DNA damage
@en
BRCA2 is ubiquitinated in vivo ...... ellular response to DNA damage
@en-gb
BRCA2 is ubiquitinated in vivo ...... ellular response to DNA damage
@nl
prefLabel
BRCA2 is ubiquitinated in vivo ...... ellular response to DNA damage
@ast
BRCA2 is ubiquitinated in vivo ...... ellular response to DNA damage
@en
BRCA2 is ubiquitinated in vivo ...... ellular response to DNA damage
@en-gb
BRCA2 is ubiquitinated in vivo ...... ellular response to DNA damage
@nl
P2093
P2860
P921
P3181
P1476
BRCA2 is ubiquitinated in vivo ...... ellular response to DNA damage
@en
P2093
Georgia Dolios
Sarah Apgar
Stuart A Aaronson
P2860
P304
P3181
P356
10.1128/MCB.24.17.7444-7455.2004
P407
P577
2004-09-01T00:00:00Z