Two pacemaker channels from human heart with profoundly different activation kinetics
about
Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophyPacemaker channel dysfunction in a patient with sinus node diseaseHypoosmotic cell swelling as a novel mechanism for modulation of cloned HCN2 channels.Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testisStructural Basis for the cAMP-dependent Gating in the Human HCN4 ChannelMolecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channelTemperature affects voltage-sensitive conductances differentially in octopus cells of the mammalian cochlear nucleusRegulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regionsDifferential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1-4 suggests evolving roles in the developing rat hippocampusProperties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotideHCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminalsIn the ventral cochlear nucleus Kv1.1 and subunits of HCN1 are colocalized at surfaces of neurons that have low-voltage-activated and hyperpolarization-activated conductances.The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart.The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotidesExploring Human Diseases and Biological Mechanisms by Protein Structure Prediction and Modeling.Mechanotransduction and hyperpolarization-activated currents contribute to spontaneous activity in mouse vestibular ganglion neuronsFunctional contributions of HCN channels in the primary auditory neurons of the mouse inner ear.Pertussis toxin sensitive and insensitive effects of adenosine and carbachol in murine atria overexpressing A(1)-adenosine receptors.GLI3 repressor controls functional development of the mouse ureterA molecular signature of tissues with pacemaker activity in the heart and upper urinary tract involves coexpressed hyperpolarization-activated cation and T-type Ca2+ channels.The pelvis-kidney junction contains HCN3, a hyperpolarization-activated cation channel that triggers ureter peristalsis.Functional expression of the hyperpolarization-activated, non-selective cation current I(f) in immortalized HL-1 cardiomyocytes.A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2.Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.P-loop residues critical for selectivity in K channels fail to confer selectivity to rabbit HCN4 channels.Caveolin-3 associates with and affects the function of hyperpolarization-activated cyclic nucleotide-gated channel 4Genetics and Sinus Node Dysfunction.Hyperpolarization-activated current (I(h)) in ganglion-cell photoreceptors.Differential distribution of four hyperpolarization-activated cation channels in mouse brain.Amino acid runs in eukaryotic proteomes and disease associations.Pacemaker oscillations in heart and brain: a key role for hyperpolarization-activated cation channels.A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews.Helical secondary structure of the external S3-S4 linker of pacemaker (HCN) channels revealed by site-dependent perturbations of activation phenotype.A homology model of the pore region of HCN channels.Targeted deletion of Kcne2 impairs HCN channel function in mouse thalamocortical circuits.Remodeling of ion channel expression in patients with chronic atrial fibrillation and mitral valvular heart disease.Functional expression of the human HCN3 channel.Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.The Contribution of HCN4 to normal sinus node function in humans and animal models
P2860
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P2860
Two pacemaker channels from human heart with profoundly different activation kinetics
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Two pacemaker channels from human heart with profoundly different activation kinetics
@ast
Two pacemaker channels from human heart with profoundly different activation kinetics
@en
Two pacemaker channels from human heart with profoundly different activation kinetics
@en-gb
Two pacemaker channels from human heart with profoundly different activation kinetics
@nl
type
label
Two pacemaker channels from human heart with profoundly different activation kinetics
@ast
Two pacemaker channels from human heart with profoundly different activation kinetics
@en
Two pacemaker channels from human heart with profoundly different activation kinetics
@en-gb
Two pacemaker channels from human heart with profoundly different activation kinetics
@nl
prefLabel
Two pacemaker channels from human heart with profoundly different activation kinetics
@ast
Two pacemaker channels from human heart with profoundly different activation kinetics
@en
Two pacemaker channels from human heart with profoundly different activation kinetics
@en-gb
Two pacemaker channels from human heart with profoundly different activation kinetics
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Two pacemaker channels from human heart with profoundly different activation kinetics
@en
P2093
P2860
P304
P3181
P356
10.1093/EMBOJ/18.9.2323
P407
P577
1999-05-04T00:00:00Z