Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia. - Wikidata - awgldk - TriplyDB

Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.

Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.

http://www.wikidata.org/entity/Q33151337

about

Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels Hyperpolarization-activated current, If, in mathematical models of rabbit sinoatrial node pacemaker cells Ion Channels in the Heart Emerging directions in the genetics of atrial fibrillation HCN channels and heart rate J-wave syndromes: Brugada and early repolarization syndromes Funny channel gene mutations associated with arrhythmias Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel Pacemaker activity of the human sinoatrial node: an update on the effects of mutations in HCN4 on the hyperpolarization-activated current Inherited conduction system abnormalities--one group of diseases, many genes Leptin decreases heart rate associated with increased ventricular repolarization via its receptor The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides Regulation of cell surface expression of functional pacemaker channels by a motif in the B-helix of the cyclic nucleotide-binding domain.Pacemaker current inhibition in experimental human cardiac sympathetic activation: a double-blind, randomized, crossover study.Genetic mapping of a new heart rate QTL on chromosome 8 of spontaneously hypertensive rats.Caveolin-3 associates with and affects the function of hyperpolarization-activated cyclic nucleotide-gated channel 4 Genetics and Sinus Node Dysfunction.PP2 prevents β-adrenergic stimulation of cardiac pacemaker activity.Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis A novel trafficking-defective HCN4 mutation is associated with early-onset atrial fibrillation.Emerging concepts in the pharmacogenomics of arrhythmias: ion channel trafficking.A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews.Resting heart rate and risk of sudden cardiac death in the general population: influence of left ventricular systolic dysfunction and heart rate-modulating drugs.Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge Cardiac ankyrins in health and disease The Contribution of HCN4 to normal sinus node function in humans and animal models Functional role of voltage gated Ca(2+) channels in heart automaticity.Enhancement of Spontaneous Activity by HCN4 Overexpression in Mouse Embryonic Stem Cell-Derived Cardiomyocytes - A Possible Biological Pacemaker.The genetic basis for inherited forms of sinoatrial dysfunction and atrioventricular node dysfunction What keeps us ticking: a funny current, a calcium clock, or both?Transcription factor ISL1 is essential for pacemaker development and function.Inhibitory effects of sevoflurane on pacemaking activity of sinoatrial node cells in guinea-pig heart.HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice Sudden cardiac death and inherited arrhythmia syndromes.Kinetic relationship between the voltage sensor and the activation gate in spHCN channels Drug-induced QT-interval shortening following antiepileptic treatment with oral rufinamide.Brugada Syndrome: Clinical, Genetic, Molecular, Cellular, and Ionic Aspects.The pacemaker current: from basics to the clinics.Risk factors in sudden death in epilepsy (SUDEP): the quest for mechanisms.

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P2860

Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.

http://www.wikidata.org/entity/Q33151337

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2004 nî lūn-bûn

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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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P2093

Akinori Kimura

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Akira Yamashina

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Hiroshi Morita

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Kazufumi Nakamura

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Kazuo Ueda

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Makoto Sunamori

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Masayasu Hiraoka

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Megumi Takahashi

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Michio Yasunami

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Natsuko Inagaki

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P2860

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

Two pacemaker channels from human heart with profoundly different activation kinetics

Cellular dysfunction of LQT5-minK mutants: abnormalities of IKs, IKr and trafficking in long QT syndrome

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

Pacemaker channel dysfunction in a patient with sinus node disease

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis

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27194-27198

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heart arrhythmia