SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity
about
Functional association between SLAP-130 and SLP-76 in Jurkat T cellsEfficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motifRecruitment and activation of PLCgamma1 in T cells: a new insight into old domainsSequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cellsA PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFATRegulatory and signaling properties of the Vav familyDifferential regulation of TCR-mediated gene transcription by Vav family membersSignalling pathways induced by protease-activated receptors and integrins in T cellsBiochemical interactions integrating Itk with the T cell receptor-initiated signaling cascadeInteraction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxinNovel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 productionRegulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zetaVav2 activates c-fos serum response element and CD69 expression but negatively regulates nuclear factor of activated T cells and interleukin-2 gene activation in T lymphocyteShb links SLP-76 and Vav with the CD3 complex in Jurkat T cellsClnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cellsMechanism and function of Vav1 localisation in TCR signalling.Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton.Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activityMolecular mechanisms underlying the evolution of the slp76 signalosome.Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoterVav proteins, adaptors and cell signaling.Positive and negative regulation of T-cell activation by adaptor proteins.CD28 costimulation: a source of Vav-1 for TCR signaling with the help of SLP-76?Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cellsAdaptors as central mediators of signal transduction in immune cells.Independent CD28 signaling via VAV and SLP-76: a model for in trans costimulation.Vav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28.Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo.Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules.The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface.Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gamma1.Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function.The chemokine CXCL12 generates costimulatory signals in T cells to enhance phosphorylation and clustering of the adaptor protein SLP-76.Macrophage activation and Fcgamma receptor-mediated signaling do not require expression of the SLP-76 and SLP-65 adaptors.Vav-induced activation of the human IFN-γ gene promoter is mediated by upregulation of AP-1 activity
P2860
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P2860
SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
SLP-76 and Vav function in sep ...... nterleukin-2 promoter activity
@ast
SLP-76 and Vav function in sep ...... nterleukin-2 promoter activity
@en
SLP-76 and Vav function in sep ...... nterleukin-2 promoter activity
@en-gb
SLP-76 and Vav function in sep ...... nterleukin-2 promoter activity
@nl
type
label
SLP-76 and Vav function in sep ...... nterleukin-2 promoter activity
@ast
SLP-76 and Vav function in sep ...... nterleukin-2 promoter activity
@en
SLP-76 and Vav function in sep ...... nterleukin-2 promoter activity
@en-gb
SLP-76 and Vav function in sep ...... nterleukin-2 promoter activity
@nl
prefLabel
SLP-76 and Vav function in sep ...... nterleukin-2 promoter activity
@ast
SLP-76 and Vav function in sep ...... nterleukin-2 promoter activity
@en
SLP-76 and Vav function in sep ...... nterleukin-2 promoter activity
@en-gb
SLP-76 and Vav function in sep ...... nterleukin-2 promoter activity
@nl
P2860
P356
P1476
SLP-76 and Vav function in sep ...... nterleukin-2 promoter activity
@en
P2093
P2860
P304
P356
10.1074/JBC.274.23.16206
P407
P577
1999-06-04T00:00:00Z