Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production - Wikidata - awgldk - TriplyDB

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production

Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production

http://www.wikidata.org/entity/Q24678315

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SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells Functional association between SLAP-130 and SLP-76 in Jurkat T cells Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation Differential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in platelets Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT GrpL, a Grb2-related adaptor protein, interacts with SLP-76 to regulate nuclear factor of activated T cell activation Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules Hematopoietic progenitor kinase 1 associates physically and functionally with the adaptor proteins B cell linker protein and SLP-76 in lymphocytes PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells The C-terminal SH3 domain of the adapter protein Grb2 binds with high affinity to sequences in Gab1 and SLP-76 which lack the SH3-typical P-x-x-P core motif Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases Characterization of Lnk. An adaptor protein expressed in lymphocytes Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130 Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase Differential regulation of activation-induced tyrosine phosphorylation and recruitment of SLP-76 to Vav by distinct isoforms of the CD45 protein-tyrosine phosphatase SLP-76 is a direct substrate of SHP-1 recruited to killer cell inhibitory receptors SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.Caspase-dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor.Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases.Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells

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Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production

http://www.wikidata.org/entity/Q24678315

description

1996 nî lūn-bûn

@nan

1996 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

1996 թվականի ապրիլին հրատարակված գիտական հոդված

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1996年の論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年論文

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1996年论文

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name

Implication of the GRB2-associ ...... iated interleukin 2 production

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Implication of the GRB2-associ ...... iated interleukin 2 production

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Implication of the GRB2-associ ...... iated interleukin 2 production

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Implication of the GRB2-associ ...... iated interleukin 2 production

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Implication of the GRB2-associ ...... iated interleukin 2 production

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Implication of the GRB2-associ ...... iated interleukin 2 production

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Implication of the GRB2-associ ...... iated interleukin 2 production

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Implication of the GRB2-associ ...... iated interleukin 2 production

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Implication of the GRB2-associ ...... iated interleukin 2 production

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Implication of the GRB2-associ ...... iated interleukin 2 production

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D G Motto

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G A Koretzky

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J Wu

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L R Hendricks-Taylor

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S E Ross

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P2860

Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells

GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor

SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases

CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line

A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells

pEF-BOS, a powerful mammalian expression vector

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line.

A functional T-cell receptor signaling pathway is required for p95vav activity.

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1937-43

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10.1084/JEM.183.4.1937

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4

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183

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8666952

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P932

2192521

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