Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
about
Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/TxkAssociation of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signalingRecruitment and activation of PLCgamma1 in T cells: a new insight into old domainsSequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cellsCooperative interactions at the SLP-76 complex are critical for actin polymerizationDifferential role of glycolipid-enriched membrane domains in glycoprotein VI- and integrin-mediated phospholipase Cgamma2 regulation in plateletsRegulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin APositive and negative regulation of T-cell activation through kinases and phosphatasesA novel function for the Tec family tyrosine kinase Itk in activation of beta 1 integrins by the T-cell receptorDeficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulationIdentification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFATT cell activationTruncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganizationMEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathwayThe role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cellsLAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathwaysThe proline rich region of the Tec homology domain of ITK regulates its activityAssociation of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinaseSLP76 and SLP65: complex regulation of signalling in lymphocytes and beyondPhosphorylation site dynamics of early T-cell receptor signalingADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugationRegulation of immune responsiveness in vivo by disrupting an early T-cell signaling event using a cell-permeable peptide.Mechanism and function of Vav1 localisation in TCR signalling.In Vivo Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell KinaseIn vivo significance of ITK-SLP-76 interaction in cytokine production.The Tec family kinase Itk exists as a folded monomer in vivo.SH2-dependent autophosphorylation within the Tec family kinase Itk.Proline isomerization preorganizes the Itk SH2 domain for binding to the Itk SH3 domain.Mechanism and functional significance of Itk autophosphorylation.T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.Itk phosphorylation sites are required for functional activity in primary T cells.The role of Gads in hematopoietic cell signalling.Persistence of cooperatively stabilized signaling clusters drives T-cell activationMolecular mechanisms underlying the evolution of the slp76 signalosome.The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma.Differential role of SLP-76 domains in T cell development and functionT-cell signaling regulated by the Tec family kinase, Itk.The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species.A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival.
P2860
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P2860
Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade
description
2000 nî lūn-bûn
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2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Biochemical interactions integ ...... or-initiated signaling cascade
@ast
Biochemical interactions integ ...... or-initiated signaling cascade
@en
Biochemical interactions integ ...... or-initiated signaling cascade
@nl
type
label
Biochemical interactions integ ...... or-initiated signaling cascade
@ast
Biochemical interactions integ ...... or-initiated signaling cascade
@en
Biochemical interactions integ ...... or-initiated signaling cascade
@nl
prefLabel
Biochemical interactions integ ...... or-initiated signaling cascade
@ast
Biochemical interactions integ ...... or-initiated signaling cascade
@en
Biochemical interactions integ ...... or-initiated signaling cascade
@nl
P2093
P2860
P3181
P356
P1476
Biochemical interactions integ ...... or-initiated signaling cascade
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.275.3.2219
P407
P577
2000-01-01T00:00:00Z