Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance
about
The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activitiesThe interaction of DNA mismatch repair proteins with human exonuclease IMolecular interactions of human Exo1 with DNARECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombinationStimulation of flap endonuclease-1 by the Bloom's syndrome proteinThe 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instabilityDNA end resection: many nucleases make light workCrystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and CleavageSaccharomyces cerevisiae RNase H(35) functions in RNA primer removal during lagging-strand DNA synthesis, most efficiently in cooperation with Rad27 nucleaseSeparation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination.Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cerevisiaeThe exonucleolytic and endonucleolytic cleavage activities of human exonuclease 1 are stimulated by an interaction with the carboxyl-terminal region of the Werner syndrome proteinDNA mismatch repair and mutation avoidance pathwaysDNA IR-Double Strand Breaks (DSBs) and cellular response via ATMPhosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks.Comprehensive classification of the PIN domain-like superfamily14-3-3 Proteins regulate exonuclease 1-dependent processing of stalled replication forksInteractions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae.Delineation of WRN helicase function with EXO1 in the replicational stress responseIdentification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavageMechanism of Holliday junction resolution by the human GEN1 proteinChromosome integrity at a double-strand break requires exonuclease 1 and MRXThe Saccharomyces cerevisiae mre11(ts) allele confers a separation of DNA repair and telomere maintenance functionsActivity of FEN1 endonuclease on nucleosome substrates is dependent upon DNA sequence but not flap orientationMechanistic analysis of Xenopus EXO1's function in 5'-strand resection at DNA double-strand breaks.Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex.14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.Human exonuclease 1 (EXO1) activity characterization and its function on flap structures.Sumoylation regulates EXO1 stability and processing of DNA damage.Morphogenetic investigation of metaphase-specific cell death in meiotic spermatocytes in mice.ATR-dependent pathways control hEXO1 stability in response to stalled forks.The role of DNA exonucleases in protecting genome stability and their impact on ageing.Unique and important consequences of RECQ1 deficiency in mammalian cells.Activities of human exonuclease 1 that promote cleavage of transcribed immunoglobulin switch regions.Links between replication and recombination in Saccharomyces cerevisiae: a hypersensitive requirement for homologous recombination in the absence of Rad27 activity.Involvement of Exo1b in DNA damage-induced apoptosisThe role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems.Exonuclease 1 and its versatile roles in DNA repair.Instability of the human minisatellite CEB1 in rad27Delta and dna2-1 replication-deficient yeast cells.
P2860
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P2860
Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Human exonuclease 1 functional ...... emoval, and mutation avoidance
@ast
Human exonuclease 1 functional ...... emoval, and mutation avoidance
@en
Human exonuclease 1 functional ...... emoval, and mutation avoidance
@en-gb
Human exonuclease 1 functional ...... emoval, and mutation avoidance
@nl
type
label
Human exonuclease 1 functional ...... emoval, and mutation avoidance
@ast
Human exonuclease 1 functional ...... emoval, and mutation avoidance
@en
Human exonuclease 1 functional ...... emoval, and mutation avoidance
@en-gb
Human exonuclease 1 functional ...... emoval, and mutation avoidance
@nl
prefLabel
Human exonuclease 1 functional ...... emoval, and mutation avoidance
@ast
Human exonuclease 1 functional ...... emoval, and mutation avoidance
@en
Human exonuclease 1 functional ...... emoval, and mutation avoidance
@en-gb
Human exonuclease 1 functional ...... emoval, and mutation avoidance
@nl
P2093
P2860
P356
P1476
Human exonuclease 1 functional ...... emoval, and mutation avoidance
@en
P2093
P2860
P304
P356
10.1074/JBC.274.25.17893
P407
P577
1999-06-18T00:00:00Z