Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases
about
Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 bindingRelationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathwayIdentification of functional domains involved in BTG1 cell localizationHuman Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcriptionPhosphorylation at intrinsically disordered regions of PAM2 motif-containing proteins modulates their interactions with PABPC1 and influences mRNA fateThe BTG2 protein is a general activator of mRNA deadenylationThe Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferationInteraction of antiproliferative protein Tob with the CCR4-NOT deadenylase complexStructural basis for the antiproliferative activity of the Tob-hCaf1 complexQuantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulationPhosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformationMechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylasesHuman TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylationMetabolic regulation of T cell differentiation and functionContribution of Orb2A stability in regulated amyloid-like oligomerization of Drosophila Orb2Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspectsTob is a negative regulator of activation that is expressed in anergic and quiescent T cellsAssociation of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complexBTG2(TIS21/PC3) induces neuronal differentiation and prevents apoptosis of terminally differentiated PC12 cellsA serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein TobAntiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome systemIdentification of the Anti-proliferative protein Tob as a MAPK substrateOsteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiationComparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD functionhCAF1/CNOT7 regulates interferon signalling by targeting STAT1.Germ-line induction of the Caenorhabditis elegans vulva.cAMP and in vivo hypoxia induce tob, ifr1, and fos expression in erythroid cells of the chick embryo.Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosisTob1 is a constitutively expressed repressor of liver regenerationThe role of antiproliferative gene Tob1 in the immune system.Preliminary study of thyroid and colon cancers-associated antigens and their cognate autoantibodies as potential cancer biomarkers.Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities.Intrinsic and extrinsic regulation of T lymphocyte quiescence.Mice lacking a transcriptional corepressor Tob are predisposed to cancer.Biological role of the two overlapping poly(A)-binding protein interacting motifs 2 (PAM2) of eukaryotic releasing factor eRF3 in mRNA decay.Dynamics of microRNAs in bull spermatozoa.BTG2 inhibits the proliferation and metastasis of osteosarcoma cells by suppressing the PI3K/AKT pathway.Genomic Analyses of Sperm Fate Regulator Targets Reveal a Common Set of Oogenic mRNAs in Caenorhabditis elegansxBtg-x regulates Wnt/beta-Catenin signaling during early Xenopus development.Crystallization and preliminary crystallographic analysis of the Tob-hCaf1 complex.
P2860
Q21266634-6844A9F7-87DB-4F5D-8838-C3B77FC7170DQ24290687-90112829-4FAE-4B4B-8003-4C1B1D5EB9E7Q24291357-E10DDF5B-C9F2-4C3B-96E2-A7DAEAC0668DQ24293751-62EBD38B-E21D-4154-9A50-95590BF0D2FCQ24310482-05E06A24-4782-46CB-B9C9-0CF9B0D2363EQ24310741-AFAF6F56-546D-482B-A581-7CA40DEB92B7Q24314993-CFB4457A-AAB0-4702-9631-B487C3CE7CFBQ24315834-96D38436-E8B7-4378-AC49-1BAD7A828708Q24319780-6229F947-A257-4185-A4CD-07CE8586CEE8Q24337126-2BDCA414-7ECB-4FD9-B9EF-324C0351213BQ24675210-1A3BC201-CE0B-4372-98DC-612AA0697828Q24675982-26AD0CB0-4956-4C0A-9D71-4C45EB54C933Q24681334-CB1C6904-A118-4EFA-80FE-15B24969E228Q26798088-89820D80-F5F3-48CD-9D45-082DDE450791Q27315988-4EC7A0A8-4398-424D-9F7D-3531E356ED64Q28202628-C678721C-EAF8-45F3-ACD6-26614A59F8AEQ28203889-39E30C02-5745-410B-AC20-0E5DE5B7BA83Q28203973-28DCA6C4-CA3B-407F-9477-5CCF5814E79FQ28205066-18D5CDB6-564B-4D95-B129-0E9E6A733814Q28205833-A9ADF30A-DE55-43BB-B5B3-C7C1A8DDDC72Q28215637-1D11B514-0DFF-4C46-BD25-D015A1AD8954Q28216566-31EA35EE-BE32-4845-945E-9960D88B2950Q28505310-F4954F92-68D9-4C0D-B3A4-AAB14E066A4EQ28577452-313FA1EA-7EE0-4C7E-B5A7-BD0AA2886F5DQ30032665-6692D4CE-0FC4-4F6B-AFA6-FE2F8F23F1D2Q30806560-E91AC845-8CF4-478A-B276-294A0D0EC6D3Q30827055-5DDBC5A1-6873-442C-B3C2-C014A75C04E7Q33696392-EF2BA81D-312A-4F7F-9D39-4D4288775B2EQ33902409-587C6033-6645-4C77-83DB-D383E2401F8AQ33951429-F2645F2C-0454-4E22-B282-6AE38217E9A8Q34276070-024BA301-EF56-4E2E-8718-FFAF9D32753EQ35806667-35A462D7-4B1E-4CBF-B0A2-7A95AE8E08FDQ35888689-A582DA5A-2E95-4052-B45B-F519F499C680Q35965343-ED7430E1-28D6-4ECD-B87F-F21F75D846B2Q36342225-8A13BBDF-AADB-4BBE-9CA7-874BE1D4FB6DQ36369084-C0A11BEA-EDD7-4B16-ADE1-E4FFA799244BQ36375110-308802E2-C6FE-45A2-A128-531C9880A4C4Q36429798-A1B140F4-9E41-4C80-91BC-47D69AD62C32Q36515900-67298B95-B05E-4819-828E-D00021357034Q36591777-65FE2918-5BF5-46E5-A53C-2F2B72399F3B
P2860
Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Tob2, a novel anti-proliferati ...... nding cyclin-dependent kinases
@ast
Tob2, a novel anti-proliferati ...... nding cyclin-dependent kinases
@en
Tob2, a novel anti-proliferati ...... nding cyclin-dependent kinases
@en-gb
Tob2, a novel anti-proliferati ...... nding cyclin-dependent kinases
@nl
type
label
Tob2, a novel anti-proliferati ...... nding cyclin-dependent kinases
@ast
Tob2, a novel anti-proliferati ...... nding cyclin-dependent kinases
@en
Tob2, a novel anti-proliferati ...... nding cyclin-dependent kinases
@en-gb
Tob2, a novel anti-proliferati ...... nding cyclin-dependent kinases
@nl
prefLabel
Tob2, a novel anti-proliferati ...... nding cyclin-dependent kinases
@ast
Tob2, a novel anti-proliferati ...... nding cyclin-dependent kinases
@en
Tob2, a novel anti-proliferati ...... nding cyclin-dependent kinases
@en-gb
Tob2, a novel anti-proliferati ...... nding cyclin-dependent kinases
@nl
P2093
P2860
P356
P1433
P1476
Tob2, a novel anti-proliferati ...... nding cyclin-dependent kinases
@en
P2093
J Fujimoto
J Kawamura-Tsuzuku
N Ikematsu
T Yamamoto
P2860
P2888
P304
P356
10.1038/SJ.ONC.1203193
P407
P577
1999-12-09T00:00:00Z
P5875
P6179
1018410759