Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein
about
Why Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding regionThe molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathyThin filament mutations: developing an integrative approach to a complex disorderChanges in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic mice.Effects of a cardiomyopathy-causing troponin t mutation on thin filament function and structure.Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy.Molecular genetics and pathogenesis of hypertrophic cardiomyopathy.Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy.Familial dilated cardiomyopathy caused by an alpha-tropomyosin mutation: the distinctive natural history of sarcomeric dilated cardiomyopathy.Molecular mechanisms of inherited cardiomyopathies.Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin.Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse.Global gene expression profiling of end-stage dilated cardiomyopathy using a human cardiovascular-based cDNA microarray.The C-terminus of troponin T is essential for maintaining the inactive state of regulated actinGene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium DesensitizationMyocardial regulatory proteins and heart failure.Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes.Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies.Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation.An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivityMechanical and energetic consequences of HCM-causing mutations.How do mutations in contractile proteins cause the primary familial cardiomyopathies?Inherited cardiomyopathies caused by troponin mutations.Heterologous expression of wild-type and mutant beta-cardiac myosin changes the contractile kinetics of cultured mouse myotubes.Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.The Delta 14 mutation of human cardiac troponin T enhances ATPase activity and alters the cooperative binding of S1-ADP to regulated actin.A simple method for measuring the relative force exerted by myosin on actin filaments in the in vitro motility assay: evidence that tropomyosin and troponin increase force in single thin filaments.Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart.Defective dynamic properties of human cardiac troponin mutations.Expression of cardiac troponin T with COOH-terminal truncation accelerates cross-bridge interaction kinetics in mouse myocardium.
P2860
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P2860
Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein
description
2000 nî lūn-bûn
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2000 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Investigation of a truncated c ...... of mutant to wild-type protein
@ast
Investigation of a truncated c ...... of mutant to wild-type protein
@en
Investigation of a truncated c ...... of mutant to wild-type protein
@en-gb
Investigation of a truncated c ...... of mutant to wild-type protein
@nl
type
label
Investigation of a truncated c ...... of mutant to wild-type protein
@ast
Investigation of a truncated c ...... of mutant to wild-type protein
@en
Investigation of a truncated c ...... of mutant to wild-type protein
@en-gb
Investigation of a truncated c ...... of mutant to wild-type protein
@nl
prefLabel
Investigation of a truncated c ...... of mutant to wild-type protein
@ast
Investigation of a truncated c ...... of mutant to wild-type protein
@en
Investigation of a truncated c ...... of mutant to wild-type protein
@en-gb
Investigation of a truncated c ...... of mutant to wild-type protein
@nl
P2093
P921
P3181
P1433
P1476
Investigation of a truncated c ...... of mutant to wild-type protein
@en
P2093
G M Esposito
H Abdulrazzak
P304
P3181
P356
10.1161/01.RES.86.11.1146
P407
P577
2000-06-09T00:00:00Z