Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia
about
Genetic architecture of body size in mammalsThe ups and downs of mutation frequencies during aging can account for the Apert syndrome paternal age effectAdvanced paternal age and reproductive outcomeThe origin of EFNB1 mutations in craniofrontonasal syndrome: frequent somatic mosaicism and explanation of the paucity of carrier malesGenetic Syndromes Associated with CraniosynostosisFibroblast growth factor signaling in skeletal development and diseaseCTNNB1 signaling in sertoli cells downregulates spermatogonial stem cell activity via WNT4Selfish spermatogonial selection: evidence from an immunohistochemical screen in testes of elderly menPaternal age effect mutations and selfish spermatogonial selection: causes and consequences for human diseaseAge and sex effects on human mutation rates: an old problem with new complexitiesPositive selection for new disease mutations in the human germline: evidence from the heritable cancer syndrome multiple endocrine neoplasia type 2B'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health careA framework for evolutionary systems biologyThe molecular anatomy of spontaneous germline mutations in human testes.Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumorsGenome-wide scans for footprints of natural selection.Molecular population genetics of PCSK9: a signature of recent positive selection.A-single spermatogonia heterogeneity and cell cycles synchronize with rat seminiferous epithelium stages VIII-IXDynamics and processes of copy number instability in human gamma-globin genes.Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm.Restoring fertility in sterile childhood cancer survivors by autotransplanting spermatogonial stem cells: are we there yet?Germline stem cells: stems of the next generation.Sex: differences in mutation, recombination, selection, gene flow, and genetic drift.Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice.Assessing human germ-cell mutagenesis in the Postgenome Era: a celebration of the legacy of William Lawson (Bill) Russell.Prevalence and complications of single-gene and chromosomal disorders in craniosynostosis.Evolution of primate gene expression.Endocrine regulation of spermatogonial stem cells in the seminiferous epithelium of adult mice.Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes.Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis.A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations.The effect of parental age on the presence of de novo mutations - Lessons from neurofibromatosis type I.New evidence for positive selection helps explain the paternal age effect observed in achondroplasiaSpermatogonial Stem Cells: Implications for Genetic Disorders and Prevention.Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors.Understanding what determines the frequency and pattern of human germline mutations.Could autism with mental retardation result from digenism and frequent de novo mutations?Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline.FGFR3 targeting strategies for achondroplasia.Cellular evidence for selfish spermatogonial selection in aged human testes.
P2860
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P2860
Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia
description
2005 nî lūn-bûn
@nan
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Gain-of-function amino acid su ...... tations in human spermatogonia
@ast
Gain-of-function amino acid su ...... tations in human spermatogonia
@en
type
label
Gain-of-function amino acid su ...... tations in human spermatogonia
@ast
Gain-of-function amino acid su ...... tations in human spermatogonia
@en
prefLabel
Gain-of-function amino acid su ...... tations in human spermatogonia
@ast
Gain-of-function amino acid su ...... tations in human spermatogonia
@en
P2093
P2860
P50
P356
P1476
Gain-of-function amino acid su ...... tations in human spermatogonia
@en
P2093
Anthony W O'Rourke
Gilean A T McVean
Steven A Wall
P2860
P304
P356
10.1073/PNAS.0500267102
P407
P577
2005-04-19T00:00:00Z