A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC
about
Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progressionGIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activationGIPC binds to the human lutropin receptor (hLHR) through an unusual PDZ domain binding motif, and it regulates the sorting of the internalized human choriogonadotropin and the density of cell surface hLHRTGF-beta: a mobile purveyor of immune privilegeA PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotypeGLUT1CBP(TIP2/GIPC1) interactions with GLUT1 and myosin VI: evidence supporting an adapter function for GLUT1CBPInteractions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptorsIdentification of endoglin in rat hepatic stellate cells: new insights into transforming growth factor beta receptor signalingFunctional proteomics, human genetics and cancer biology of GIPC family membersThe type III TGF-beta receptor regulates epithelial and cancer cell migration through beta-arrestin2-mediated activation of Cdc42.The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells.The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.Therapeutic implications of GIPC1 silencing in cancerHuman papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasomeNative human autoantibodies targeting GIPC1 identify differential expression in malignant tumors of the breast and ovaryIntegrating multiple microarray data for cancer pathway analysis using bootstrapping K-S test.Integrin alpha5beta1 function is regulated by XGIPC/kermit2 mediated endocytosis during Xenopus laevis gastrulation.The type III TGF-beta receptor suppresses breast cancer progression through GIPC-mediated inhibition of TGF-beta signaling.Endoglin in liver fibrogenesis: Bridging basic science and clinical practiceType III transforming growth factor-beta (TGF-beta) receptor mediates apoptosis in renal cell carcinoma independent of the canonical TGF-beta signaling pathwayERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish.Roles for the type III TGF-beta receptor in human cancerTransforming growth factor beta receptor type III is a tumor promoter in mesenchymal-stem like triple negative breast cancer.Association between genetic variations of the transforming growth factor ß receptor type III and asthma in a Korean population.Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta.Ectodomain shedding of TβRIII is required for TβRIII-mediated suppression of TGF-β signaling and breast cancer migration and invasion.GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion.Cell signaling pathways in vertebrate lens regeneration.Molecular characterization and ligand binding specificity of the PDZ domain-containing protein GIPC3 from Schistosoma japonicum.The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA.Regulation of growth factor receptor degradation by ADP-ribosylation factor domain protein (ARD) 1.BMP-2 and TGFβ2 shared pathways regulate endocardial cell transformation.GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signalingInteractions between GIPC-APPL and GIPC-TRP1 regulate melanosomal protein trafficking and melanogenesis in human melanocytes.The type III TGF-beta receptor suppresses breast cancer progressionSignaling mechanisms of the epithelial-mesenchymal transition.The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behaviorTGFβ and BMP-2 regulate epicardial cell invasion via TGFβR3 activation of the Par6/Smurf1/RhoA pathway.How regulators of G protein signaling achieve selective regulation.A common variant near TGFBR3 is associated with primary open angle glaucoma.
P2860
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P2860
A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
A novel mechanism for regulati ...... h the PDZ domain protein, GIPC
@ast
A novel mechanism for regulati ...... h the PDZ domain protein, GIPC
@en
A novel mechanism for regulati ...... h the PDZ domain protein, GIPC
@en-gb
A novel mechanism for regulati ...... h the PDZ domain protein, GIPC
@nl
type
label
A novel mechanism for regulati ...... h the PDZ domain protein, GIPC
@ast
A novel mechanism for regulati ...... h the PDZ domain protein, GIPC
@en
A novel mechanism for regulati ...... h the PDZ domain protein, GIPC
@en-gb
A novel mechanism for regulati ...... h the PDZ domain protein, GIPC
@nl
prefLabel
A novel mechanism for regulati ...... h the PDZ domain protein, GIPC
@ast
A novel mechanism for regulati ...... h the PDZ domain protein, GIPC
@en
A novel mechanism for regulati ...... h the PDZ domain protein, GIPC
@en-gb
A novel mechanism for regulati ...... h the PDZ domain protein, GIPC
@nl
P2093
P3181
P356
P1476
A novel mechanism for regulati ...... h the PDZ domain protein, GIPC
@en
P2093
P304
P3181
P356
10.1074/JBC.M106831200
P407
P577
2001-10-26T00:00:00Z