Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains
about
Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathwaysStructural and functional studies on platelet-derived growth factorPDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularlyInverse correlation between PDGFC expression and lymphocyte infiltration in human papillary thyroid carcinomas.PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors.A potential oncogenic activity of platelet-derived growth factor d in prostate cancer progressionAutocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors.PAPSS2 promotes alkaline phosphates activity and mineralization of osteoblastic MC3T3-E1 cells by crosstalk and Smads signal pathways.Complementation of two related tumour cell classes during experimental metastasis tagged with different histochemical marker genes.Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice.Adherence-dependent increase in human monocyte PDGF(B) mRNA is associated with increases in c-fos, c-jun, and EGR2 mRNA.Accumulation of PDGF B and cell-binding forms of PDGF A in the extracellular matrixBiological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences.Phosphorylation of tyrosine 720 in the platelet-derived growth factor alpha receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation.Immunochemical localization of the epitope for a monoclonal antibody that neutralizes human platelet-derived growth factor mitogenic activityAlternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian speciesThe alternatively spliced exon of the platelet-derived growth factor A chain encodes a nuclear targeting signal.Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172).Biological activities of fibroblast growth factors.Platelet-derived growth factor: mechanism of action and possible in vivo function.PDGF and PDGF receptors in glioma.In vivo footprinting and functional analysis of the human c-sis/PDGF B gene promoter provides evidence for two binding sites for transcriptional activators.Proprotein convertase 5/6 cleaves platelet-derived growth factor A in the human endometrium in preparation for embryo implantation.VEGF-null cells require PDGFR alpha signaling-mediated stromal fibroblast recruitment for tumorigenesis.Aberrant expression of platelet-derived growth factor A-chain cDNAs due to cryptic splicing of RNA transcripts in COS-1 cells.The oncogene PDGF-B provides a key switch from cell death to survival induced by TNF.Identification of a cell retention signal in the B-chain of platelet-derived growth factor and in the long splice version of the A-chain.The aetiology of clubbing and hypertrophic osteoarthropathy.Platelet-derived growth factor-dependent cellular transformation requires either phospholipase Cgamma or phosphatidylinositol 3 kinase.Pathogenesis of pulmonary fibrosis in interstitial lung disease. Alveolar macrophage PDGF(B) gene activation and up-regulation by interferon gamma.Identification of a domain within the carboxyl-terminal region of the beta platelet-derived growth factor (PDGF) receptor that mediates the high transforming activity of PDGF.Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant.Tumorigenic conversion of human mesothelial cells as a consequence of platelet-derived growth factor-A chain overexpression.Dexamethasone-induced increase in platelet-derived growth factor (B) mRNA in human alveolar macrophages and myelomonocytic HL60 macrophage-like cells.Platelet-derived growth factor (PDGF) receptor-alpha activates c-Jun NH2-terminal kinase-1 and antagonizes PDGF receptor-beta -induced phenotypic transformation.Platelet-derived growth factor (PDGF) receptor-alpha-activated c-Jun NH2-terminal kinase-1 is critical for PDGF-induced p21WAF1/CIP1 promoter activity independent of p53.Effectiveness of intensive case management for substance-dependent women receiving temporary assistance for needy families.Differential Requirement of a Motif within the Carboxyl-terminal Domain of α-Platelet-derived Growth Factor (αPDGF) Receptor for PDGF Focus Forming Activity Chemotaxis, or Growth
P2860
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P2860
Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains
description
1988 nî lūn-bûn
@nan
1988 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1988 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
name
Comparison of biological prope ...... human PDGF-A and PDGF-B chains
@ast
Comparison of biological prope ...... human PDGF-A and PDGF-B chains
@en
Comparison of biological prope ...... human PDGF-A and PDGF-B chains
@en-gb
Comparison of biological prope ...... human PDGF-A and PDGF-B chains
@nl
type
label
Comparison of biological prope ...... human PDGF-A and PDGF-B chains
@ast
Comparison of biological prope ...... human PDGF-A and PDGF-B chains
@en
Comparison of biological prope ...... human PDGF-A and PDGF-B chains
@en-gb
Comparison of biological prope ...... human PDGF-A and PDGF-B chains
@nl
prefLabel
Comparison of biological prope ...... human PDGF-A and PDGF-B chains
@ast
Comparison of biological prope ...... human PDGF-A and PDGF-B chains
@en
Comparison of biological prope ...... human PDGF-A and PDGF-B chains
@en-gb
Comparison of biological prope ...... human PDGF-A and PDGF-B chains
@nl
P2093
P356
P1433
P1476
Comparison of biological prope ...... human PDGF-A and PDGF-B chains
@en
P2093
C H Heldin
E Di Marco
K C Robbins
M P Beckmann
P P Di Fiore
S A Aaronson
P304
P356
10.1126/SCIENCE.2842868
P407
P577
1988-09-09T00:00:00Z