Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways - Wikidata - awgldk - TriplyDB

Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways

Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways

http://www.wikidata.org/entity/Q24311693

about

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors Macrophage-colony-stimulating factor (CSF-1) induces proliferation, chemotaxis, and reversible monocytic differentiation in myeloid progenitor cells transfected with the human c-fms/CSF-1 receptor cDNA Class III receptor tyrosine kinases: role in leukaemogenesis.Isoform-specific regulation of platelet-derived growth factor activity and binding in osteoblast-enriched cultures from fetal rat bone.Blockade of platelet-derived growth factor receptor-beta pathway induces apoptosis of vascular endothelial cells and disrupts glomerular capillary formation in neonatal mice Mutational analysis of the beta-type platelet-derived growth factor receptor defines the site of interaction with the bovine papillomavirus type 1 E5 transforming protein.Developmental expression of the platelet-derived growth factor alpha-receptor gene in mammalian central nervous system.Platelet-derived growth factor is a potent biologic response modifier of T cells Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction.The chemotactic response to PDGF-BB: evidence of a role for Ras.Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences.The bovine papillomavirus type 1 E5 transforming protein specifically binds and activates the beta-type receptor for the platelet-derived growth factor but not other related tyrosine kinase-containing receptors to induce cellular transformation.Stimulation of the platelet-derived growth factor beta receptor signaling pathway activates protein kinase C-delta.Induction of the granulocyte-macrophage colony-stimulating factor (CSF) receptor by granulocyte CSF increases the differentiative options of a murine hematopoietic progenitor cell.High-efficiency identification of genes by functional analysis from a retroviral cDNA expression library.A colony-stimulating factor 1 (CSF-1) receptor/platelet-derived growth factor-beta receptor gene fusion confers CSF-1 independence and tumorigenicity on a c-myc-immortalized monocyte cell line Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells Interleukin (IL)-2 and IL-3 induce distinct but overlapping responses in murine IL-3-dependent 32D cells transduced with human IL-2 receptor beta chain: involvement of tyrosine kinase(s) other than p56lck.Human neuroblastoma cells express alpha and beta platelet-derived growth factor receptors coupling with neurotrophic and chemotactic signaling.Identification of a domain within the carboxyl-terminal region of the beta platelet-derived growth factor (PDGF) receptor that mediates the high transforming activity of PDGF.Gastrin receptor gene expression in several human carcinomas.Signal transduction for PDGF-induced chemotaxis of vascular smooth muscle cells.Differences in binding to the solid substratum and extracellular matrix may explain isoform-specific paracrine effects of platelet-derived growth factor.PDGF alpha- and beta-receptors activate unique and common signal transduction pathways.Mitogenic signal transduction in normal and transformed 32D hematopoietic cells.Relative platelet-derived growth factor receptor subunit expression determines cell migration to different dimeric forms of PDGF.Molecular mechanisms of OLIG2 transcription factor in brain cancer.Retinoic acid suppresses the response to platelet-derived growth factor in human hepatic Ito-cell-like myofibroblasts: a post-receptor mechanism independent of raf/fos/jun/egr activation.Platelet-derived growth factor (PDGF)-AB-mediated phosphorylation of PDGF beta receptors.The expression of PDGF-alpha but not PDGF-beta receptors is suppressed in Swiss/3T3 fibroblasts over-expressing protein kinase C-alpha.Phosphatidylinositol 3-kinase-independent signal transduction pathway for platelet-derived growth factor-induced chemotaxis.Antiproliferative effect of a novel cholecystokinin-B/gastrin receptor antagonist, YM022.A small GTP-binding protein, Rho, associates with the platelet-derived growth factor type-beta receptor upon ligand binding.Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds.Peritoneal morphological and functional changes associated with platelet-derived growth factor B.

P2860

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P2860

Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways

http://www.wikidata.org/entity/Q24311693

description

1989 nî lūn-bûn

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1989 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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1989 թվականի նոյեմբերին հրատարակված գիտական հոդված

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1989年の論文

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Independent expression of huma ...... chemotactic signaling pathways

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Independent expression of huma ...... chemotactic signaling pathways

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Proceedings of the National Academy of Sciences of the United States of America

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Independent expression of huma ...... chemotactic signaling pathways

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J H Pierce

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J S Greenberger

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M Ruggiero

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S A Aaronson

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T P Fleming

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W J LaRochelle

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P2860

Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains

cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

A new generation of Ca2+ indicators with greatly improved fluorescence properties

Signal transduction by the platelet-derived growth factor receptor

Role of phosphatidylinositol kinase in PDGF receptor signal transduction

Preparation of iodine-131 labelled human growth hormone of high specific activity

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

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regulation of chemotaxis

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298271

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