Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
about
Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligaseEmi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitorThe tumor suppressor CYLD regulates entry into mitosisPlk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBoraRegulation of late G1/S phase transition and APC Cdh1 by reactive oxygen speciesProphase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)Polo-like kinase 1, on the rise from cell cycle regulation to prostate cancer developmentFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisModulation of cell cycle control during oocyte-to-embryo transitionsMultiple requirements of PLK1 during mouse oocyte maturationHypersensitivity to DNA damage in antephase as a safeguard for genome stability.The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradationSpatiotemporal regulation of the anaphase-promoting complex in mitosisPlk1- and beta-TrCP-dependent degradation of Bora controls mitotic progressionThe SCF ubiquitin ligase: insights into a molecular machineUbiquitin and SUMO systems in the regulation of mitotic checkpointsFBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrestMouse emi1 has an essential function in mitotic progression during early embryogenesisRegulation of postsynaptic RapGAP SPAR by Polo-like kinase 2 and the SCFbeta-TRCP ubiquitin ligase in hippocampal neuronsCdk1, Plks, Auroras, and Neks: the mitotic bodyguardsThe anaphase promoting complex/cyclosome: a machine designed to destroySpatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling.The APC/C inhibitor, Emi1, is essential for prevention of rereplicationAPC/C--the master controller of origin licensing?Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/COscillation of APC/C activity during cell cycle arrest promotes centrosome amplification.Wrenches in the works: drug discovery targeting the SCF ubiquitin ligase and APC/C complexes.Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases.Regulation of APC/C activators in mitosis and meiosis.Polo-box domain: a versatile mediator of polo-like kinase function.Regulatory functional territory of PLK-1 and their substrates beyond mitosis.A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs.Phosphorylation-mediated stabilization of Bora in mitosis coordinates Plx1/Plk1 and Cdk1 oscillationsLink between DNA damage and centriole disengagement/reduplication in untransformed human cells.Rapid determination of multiple linear kinase substrate motifs by mass spectrometryRereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase.
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P2860
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
description
2004 nî lūn-bûn
@nan
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
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2004年论文
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Role of Polo-like kinase in th ...... se promoting complex/cyclosome
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Role of Polo-like kinase in th ...... se promoting complex/cyclosome
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Role of Polo-like kinase in th ...... se promoting complex/cyclosome
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Role of Polo-like kinase in th ...... se promoting complex/cyclosome
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Role of Polo-like kinase in th ...... se promoting complex/cyclosome
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Role of Polo-like kinase in th ...... se promoting complex/cyclosome
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Role of Polo-like kinase in th ...... se promoting complex/cyclosome
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Role of Polo-like kinase in th ...... se promoting complex/cyclosome
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Role of Polo-like kinase in th ...... se promoting complex/cyclosome
@ast
Role of Polo-like kinase in th ...... se promoting complex/cyclosome
@en
Role of Polo-like kinase in th ...... se promoting complex/cyclosome
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Role of Polo-like kinase in th ...... se promoting complex/cyclosome
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Role of Polo-like kinase in th ...... se promoting complex/cyclosome
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Jérôme Boulaire
Yakir Moshe
P2860
P304
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10.1073/PNAS.0402442101
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2004-05-25T00:00:00Z