Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor
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Targeted disruption of heparan sulfate interaction with hepatocyte and vascular endothelial growth factors blocks normal and oncogenic signalingStructural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1Protein characterization of a candidate mechanism SNP for Crohn's disease: the macrophage stimulating protein R689C substitutionA novel adaptation of the integrin PSI domain revealed from its crystal structureStructural basis of semaphorin-plexin signallingStructural basis for the binding specificity of human Recepteur d'Origine Nantais (RON) receptor tyrosine kinase to macrophage-stimulating proteinStructural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase.The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signalingAn uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in miceTargeting the hepatocyte growth factor-cMET axis in cancer therapyThe MET axis as a therapeutic target.c-Met as a Target for Personalized TherapyUnderstanding cell signalling systems: paving the way for new therapiesMET: a critical player in tumorigenesis and therapeutic targetA mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonistStructural basis for agonism and antagonism of hepatocyte growth factorCrystal Structure of the Sema-PSI Extracellular Domain of Human RON Receptor Tyrosine KinaseEngineered variants of InlB with an additional leucine-rich repeat discriminate between physiologically relevant and packing contacts in crystal structures of the InlB:MET complexMonovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agentAn allosteric switch for pro-HGF/Met signaling using zymogen activator peptidesFunctional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk alleleBiology of MET: a double life between normal tissue repair and tumor progressionBiological function derived from predicted structures in CASP11.Four individually druggable MET hotspots mediate HGF-driven tumor progression.Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.Sequence and structural analysis of the Asp-box motif and Asp-box beta-propellers; a widespread propeller-type characteristic of the Vps10 domain family and several glycoside hydrolase familiesHigh incidence of ErbB3, ErbB4, and MET expression in ovarian cancer.Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET.Human hepatocyte growth factor receptor is a cellular coreceptor for adeno-associated virus serotype 3Structural basis of hepatocyte growth factor/scatter factor and MET signalling.Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cellsHGF and MET mutations in primary and secondary lymphedemaReceptor-tyrosine-kinase-targeted therapies for head and neck cancer.Molecularly targeted therapies in non-small-cell lung cancer annual update 2014The role of the c-Met pathway in lung cancer and the potential for targeted therapy.Artificial human Met agonists based on macrocycle scaffoldsUtilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonistAptamers Binding to c-Met Inhibiting Tumor Cell MigrationGene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis.Crizotinib (PF02341066) as a ALK /MET inhibitor- Special Emphasis as a Therapeutic Drug Against Lung Cancer.
P2860
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P2860
Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Crystal structure of the HGF b ...... ema domain of the Met receptor
@ast
Crystal structure of the HGF b ...... ema domain of the Met receptor
@en
Crystal structure of the HGF b ...... ema domain of the Met receptor
@en-gb
Crystal structure of the HGF b ...... ema domain of the Met receptor
@nl
type
label
Crystal structure of the HGF b ...... ema domain of the Met receptor
@ast
Crystal structure of the HGF b ...... ema domain of the Met receptor
@en
Crystal structure of the HGF b ...... ema domain of the Met receptor
@en-gb
Crystal structure of the HGF b ...... ema domain of the Met receptor
@nl
prefLabel
Crystal structure of the HGF b ...... ema domain of the Met receptor
@ast
Crystal structure of the HGF b ...... ema domain of the Met receptor
@en
Crystal structure of the HGF b ...... ema domain of the Met receptor
@en-gb
Crystal structure of the HGF b ...... ema domain of the Met receptor
@nl
P2093
P2860
P3181
P356
P1433
P1476
Crystal structure of the HGF b ...... ema domain of the Met receptor
@en
P2093
Daniel Kirchhofer
Jennifer Stamos
Robert A Lazarus
Xiaoyi Yao
P2860
P304
P3181
P356
10.1038/SJ.EMBOJ.7600243
P407
P577
2004-05-27T00:00:00Z