The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells
about
Ribosomopathies: how a common root can cause a tree of pathologiesStructure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activationInterleukin 6 downregulates p53 expression and activity by stimulating ribosome biogenesis: a new pathway connecting inflammation to cancerCockayne syndrome protein A is a transcription factor of RNA polymerase I and stimulates ribosomal biogenesis and growthRibosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implicationsSelective inhibition of rDNA transcription by a small-molecule peptide that targets the interface between RNA polymerase I and Rrn3.MDM2-p53 pathway in hepatocellular carcinoma.Acrofacial Dysostosis, Cincinnati Type, a Mandibulofacial Dysostosis Syndrome with Limb Anomalies, Is Caused by POLR1A Dysfunction.Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stressPHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesisLKB1 promotes cell survival by modulating TIF-IA-mediated pre-ribosomal RNA synthesis under uridine downregulated conditions5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint.The emerging role of RNA polymerase I transcription machinery in human malignancy: a clinical perspective.p53 -Dependent and -Independent Nucleolar Stress Responses.p53 and ribosome biogenesis stress: the essentials.mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels.Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity.p73 expression is regulated by ribosomal protein RPL26 through mRNA translation and protein stability.Recruitment of RPL11 at promoter sites of p53-regulated genes upon nucleolar stress through NEDD8 and in an Mdm2-dependent manner.Therapeutic dosages of aspirin counteract the IL-6 induced pro-tumorigenic effects by slowing down the ribosome biogenesis rate.Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation.The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibitionRapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells.Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells.FGFR2 mutations in bent bone dysplasia syndrome activate nucleolar stress and perturb cell fate determination.Up-regulation of small nucleolar RNA 78 is correlated with aggressive phenotype and poor prognosis of hepatocellular carcinoma.Ribosomal proteins: insight into molecular roles and functions in hepatocellular carcinoma.Experimental Autoimmune Encephalomyelitis Ameliorated by Passive Transfer of Polymerase 1-Silenced MOG35-55 Lymphatic Node Cells: Verification of a Novel Therapeutic Approach in Multiple Sclerosis.Global expression analysis of the response to microaerobiosis reveals an important cue for endophytic establishment of Azoarcus sp. BH72.MDM2-p53 Interactions in Human Hepatocellular Carcinoma: What Is the Role of Nutlins and New Therapeutic Options?JHDM1B expression regulates ribosome biogenesis and cancer cell growth in a p53 dependent manner.Treating hematological malignancies with drugs inhibiting ribosome biogenesis: when and why.
P2860
Q26781845-A8B8344F-7CD2-4A94-AA11-EDF874093AA1Q27322960-73166B72-0BCD-469B-BB09-F84FF163862FQ34116561-E18A2E7C-7007-48DC-801B-8BABED3ABC59Q34417956-EB8B26AA-ACBE-494F-99FD-63CA4EA45C7EQ34435519-C69A9976-BCD4-4DCB-9445-8ACA9AD0E692Q35208439-B76CBBDC-7C9D-4A33-B61A-5FD5CFAC92BDQ35857579-1A901A83-F546-438D-8808-B80024DB0C69Q36060880-5FB4F1E0-456B-4480-8E24-E96557C76E95Q36483813-E0B0F30F-4537-47BE-ADF0-D3F49548D996Q36579495-6EDBCDE4-8C5C-4315-8737-A2EFBEF67E5FQ36771843-33673EB2-BD68-4AAC-B985-DD9ECC8C1D7DQ37592131-F8B15532-EBAB-4B9A-84BC-83F5AB4A894AQ38124258-3E48E702-08C3-4DDC-A802-97B03D8237BCQ38202877-B7AAA00A-7C06-4B7A-B87A-E4FF8440C743Q38205676-96EFB4C5-4DB2-41AA-A0CD-28FD728CE9B3Q38931429-66BB27AA-5335-4291-9493-A05A0BC40584Q39092667-6487890C-ED34-46FE-8809-839EA75CB3E2Q39204379-15558C9D-781A-4DEC-B41A-B3F7930C1EE6Q39256295-D3C43E13-92AA-4A3A-870F-3B3B4E0147A3Q39457252-C54632F9-6213-41E9-8567-D96E12669A0EQ39482087-AABD13DF-2E8D-4DF9-ABEB-1B2F1FD0F032Q41821574-6C8EB521-ED8A-4230-B294-AD37D44B1982Q42371463-C881D89D-CFE4-44FF-9061-5C722F608023Q42428228-5387A4AE-B0D3-42ED-95BD-2B895FF5170CQ43441639-7DB9F8B0-38C1-446E-B707-0CF84987F3DFQ46473475-30BDADA8-FEAA-4C05-AA46-6A0C96970C46Q47748537-561E275A-28F2-497F-A2D1-81FB5BFAA940Q48709222-D6CBC527-67D0-451D-8201-EE1D2CA02B41Q51406818-AE7E242A-8DEB-453B-8176-8DE8BAEDA9B7Q52340395-8995D41E-7A45-469C-BD61-01C0C7D4EF85Q54190030-D0CBC5B9-0444-434A-B269-AD87E1F0E410Q54977441-89B50C02-FBAC-4AAD-86D1-8D1FE298C928
P2860
The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The balance between rRNA and r ...... pressor p53 in mammalian cells
@ast
The balance between rRNA and r ...... pressor p53 in mammalian cells
@en
The balance between rRNA and r ...... pressor p53 in mammalian cells
@en-gb
The balance between rRNA and r ...... pressor p53 in mammalian cells
@nl
type
label
The balance between rRNA and r ...... pressor p53 in mammalian cells
@ast
The balance between rRNA and r ...... pressor p53 in mammalian cells
@en
The balance between rRNA and r ...... pressor p53 in mammalian cells
@en-gb
The balance between rRNA and r ...... pressor p53 in mammalian cells
@nl
prefLabel
The balance between rRNA and r ...... pressor p53 in mammalian cells
@ast
The balance between rRNA and r ...... pressor p53 in mammalian cells
@en
The balance between rRNA and r ...... pressor p53 in mammalian cells
@en-gb
The balance between rRNA and r ...... pressor p53 in mammalian cells
@nl
P2093
P2860
P356
P1433
P1476
The balance between rRNA and r ...... pressor p53 in mammalian cells
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2011.48
P407
P577
2011-03-14T00:00:00Z
P5875
P6179
1005491824