Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation - Wikidata - awgldk - TriplyDB

Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation

Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation

http://www.wikidata.org/entity/Q24564177

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The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1.Ribosomal protein S27L is a direct p53 target that regulates apoptosis Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation Regulation of nucleolar signalling to p53 through NEDDylation of L11 Ribosomal proteins are targets for the NEDD8 pathway Inhibition of c-Myc activity by ribosomal protein L11 MDMX regulation of p53 response to ribosomal stress Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2 Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26 Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism Targeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1 Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification 4-thiouridine inhibits rRNA synthesis and causes a nucleolar stress response Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradation Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response.Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction Regulation of peroxisome proliferator-activated receptor-alpha by MDM2.Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11.Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response.JAZ mediates G1 cell-cycle arrest and apoptosis by positively regulating p53 transcriptional activity.Uncoupling ribosome biogenesis regulation from RNA polymerase I activity during herpes simplex virus type 1 infection Polyadenylation and degradation of incomplete RNA polymerase I transcripts in mammalian cells.Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation Ribosomal protein L11 associates with c-Myc at 5 S rRNA and tRNA genes and regulates their expression Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24 MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis

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Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation

http://www.wikidata.org/entity/Q24564177

description

2004 nî lūn-bûn

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2004 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2004 թվականի հունիսին հրատարակված գիտական հոդված

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2004年の論文

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2004年学术文章

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Essential role of ribosomal pr ...... ibition-induced p53 activation

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Essential role of ribosomal pr ...... ibition-induced p53 activation

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Essential role of ribosomal pr ...... ibition-induced p53 activation

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Essential role of ribosomal pr ...... ibition-induced p53 activation

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Essential role of ribosomal pr ...... ibition-induced p53 activation

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Essential role of ribosomal pr ...... ibition-induced p53 activation

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Essential role of ribosomal pr ...... ibition-induced p53 activation

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SJ.EMBOJ.7600247

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The EMBO Journal

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Essential role of ribosomal pr ...... ibition-induced p53 activation

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Aiwen Jin

http://www.w3.org/2001/XMLSchema#string

Krishna P Bhat

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Yanping Zhang

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P2860

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

Mdm2 promotes the rapid degradation of p53

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Repression of p53-mediated transcription by MDM2: a dual mechanism

Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway

Regulation of p53 stability by Mdm2

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423289

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