Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress - Wikidata - awgldk - TriplyDB

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

http://www.wikidata.org/entity/Q36483813

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The importance of ribosome production, and the 5S RNP-MDM2 pathway, in health and disease Ribosomopathies: how a common root can cause a tree of pathologies Targeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress Nucleolar stress induces ubiquitination-independent proteasomal degradation of PICT1 protein PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis Nucleolar stress with and without p53.Marrow failure: a window into ribosome biology Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications Ribosomopathies and the paradox of cellular hypo- to hyperproliferation.Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress Chilling acclimation provides immunity to stress by altering regulatory networks and inducing genes with protective functions in cassava The roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells.PICT1 expression is a poor prognostic factor in non-small cell lung cancer.Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network Comparative proteomics analysis of Spodoptera frugiperda cells during Autographa californica multiple nucleopolyhedrovirus infection A liaison between mTOR signaling, ribosome biogenesis and cancer Regulatory role of rpL3 in cell response to nucleolar stress induced by Act D in tumor cells lacking functional p53 Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis Repressed synthesis of ribosomal proteins generates protein-specific cell cycle and morphological phenotypes.Tissue specific roles for the ribosome biogenesis factor Wdr43 in zebrafish development.5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint.Ribosomal proteins as novel players in tumorigenesis.p53 and ribosome biogenesis stress: the essentials.GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.Probing the mechanisms underlying human diseases in making ribosomes.mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels.Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP.Proteome complexity and the forces that drive proteome imbalance.Physical and functional interaction of the TPL2 kinase with nucleophosmin.Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex.Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity.RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance.Ribosomopathy-like properties of murine and human cancers.

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P2860

Mutual protection of ribosomal proteins L5 and L11 from degradation is essential for p53 activation upon ribosomal biogenesis stress

http://www.wikidata.org/entity/Q36483813

description

2012 nî lūn-bûn

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Mutual protection of ribosomal ...... on ribosomal biogenesis stress

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Mutual protection of ribosomal ...... on ribosomal biogenesis stress

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PNAS.1218535109

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Proceedings of the National Academy of Sciences of the United States of America

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Mutual protection of ribosomal ...... on ribosomal biogenesis stress

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Carol Prives

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Chen Katz

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Lilyn Daftuar

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Lior Golomb

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Maja Cokarić Brdovčak

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Sladana Bursać

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Vedrana Filić

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Yan Zhu

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P2860

Nucleolar proteome dynamics

Directed proteomic analysis of the human nucleolus

PML regulates p53 stability by sequestering Mdm2 to the nucleolus

The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

Regulation of nucleolar signalling to p53 through NEDDylation of L11

The role of human ribosomal proteins in the maturation of rRNA and ribosome production

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation

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20467-20472

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10.1073/PNAS.1218535109

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50

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109

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Sinisa Volarevic

Kristina Grabusic

Martin Pfannkuchen

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2012-11-20T00:00:00Z

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233738623

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23169665

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3528581

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