Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease - Wikidata - awgldk - TriplyDB

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

http://www.wikidata.org/entity/Q24298408

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β-Amyloid: the key peptide in the pathogenesis of Alzheimer's disease Alzheimer's therapeutics: translation of preclinical science to clinical drug development Receptor tyrosine kinases in the nucleus Cellular mechanisms of γ-secretase substrate selection, processing and toxicity The role of mammalian sirtuins in the regulation of metabolism, aging, and longevity Protease regulation: the Yin and Yang of neural development and disease Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage APP intracellular domain-WAVE1 pathway reduces amyloid-β production.Structural insights into H+-coupled multidrug extrusion by a MATE transporter APP processing in Alzheimer's disease Complex regulation of γ-secretase: from obligatory to modulatory subunits Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's disease An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progress Preclinical Assessment of Young Blood Plasma for Alzheimer Disease.Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.Immune and myodegenerative pathomechanisms in inclusion body myositis Synthesis and evaluation of indole-based chalcones as inducers of methuosis, a novel type of nonapoptotic cell death.Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain.The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.Exploiting protein-protein interaction networks for genome-wide disease-gene prioritization Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.Target deconvolution techniques in modern phenotypic profiling.Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine.The γ-secretase complex: from structure to function.A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase.Gamma secretase-activating protein is a substrate for caspase-3: implications for Alzheimer's disease Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.Physiology and pathology of endosome-to-Golgi retrograde sorting.Nontranscriptional role of Hif-1α in activation of γ-secretase and notch signaling in breast cancer.Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates.Degradation of gamma secretase activating protein by the ubiquitin-proteasome pathway.Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease.New pathway links γ-secretase to inflammation and memory while sparing notch.Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence

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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

http://www.wikidata.org/entity/Q24298408

description

2010 nî lūn-bûn

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2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

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type

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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

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prefLabel

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

@ast

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

@en

Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

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Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease

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Christine Remmers

http://www.w3.org/2001/XMLSchema#string

Fred Gorelick

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Gen He

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Joseph Hendrick

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Karima Bettayeb

http://www.w3.org/2001/XMLSchema#string

Peng Li

http://www.w3.org/2001/XMLSchema#string

Wenjie Luo

http://www.w3.org/2001/XMLSchema#string

William J Netzer

http://www.w3.org/2001/XMLSchema#string

P2860

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

Gleevec inhibits beta-amyloid production but not Notch cleavage

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis.

Alzheimer's disease: genes, proteins, and therapy

Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.

Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial.

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10.1038/NATURE09325

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7311

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467

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Lawrence Paul Wennogle

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2010-09-02T00:00:00Z

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46111176

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1019910783

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20811458

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Alzheimer's disease

positive regulation of amyloid-beta formation

Gamma-secretase activating protein

Gamma-secretase activating protein

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2936959

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