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Structural diversity of eukaryotic membrane cytochrome p450s

Structural diversity of eukaryotic membrane cytochrome p450s

http://www.wikidata.org/entity/Q27025716

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Electron flow through biological molecules: does hole hopping protect proteins from oxidative damage?DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function Structural basis for the 4'-hydroxylation of diclofenac by a microbial cytochrome P450 monooxygenase Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE Molecular dynamics of CYP2D6 polymorphisms in the absence and presence of a mechanism-based inactivator reveals changes in local flexibility and dominant substrate access channels Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5.Contributions of ionic interactions and protein dynamics to cytochrome P450 2D6 (CYP2D6) substrate and inhibitor binding.The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ω-Hydroxylation.The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction.Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia.Recent Structural Insights into Cytochrome P450 Function.Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.Could tyrosine and tryptophan serve multiple roles in biological redox processes?Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison.Biphenyl 4-Hydroxylases Involved in Aucuparin Biosynthesis in Rowan and Apple Are Cytochrome P450 736A Proteins.Substrate Hunting for the Myxobacterial CYP260A1 Revealed New 1α-Hydroxylated Products from C-19 Steroids.In Silico Predictions of Drug - Drug Interactions Caused by CYP1A2, 2C9 and 3A4 Inhibition - a Comparative Study of Virtual Screening Performance.Genome-Wide Analysis, Classification, Evolution, and Expression Analysis of the Cytochrome P450 93 Family in Land Plants.The Localization of Cytochrome P450s CYP1A1 and CYP1A2 into Different Lipid Microdomains Is Governed by Their N-terminal and Internal Protein Regions.Mechanism of drug-drug interactions mediated by human cytochrome P450 CYP3A4 monomer Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism New trends in cytochrome p450 research at the half-century mark Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges.Physical Studies of P450-P450 Interactions: Predicting Quaternary Structures of P450 Complexes in Membranes from Their X-ray Crystal Structures.Functional characterization of cytochromes P450 2B from the desert woodrat Neotoma lepida.Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes.The catalytic function of cytochrome P450 is entwined with its membrane-bound nature.Cytochrome P450 structure-function: insights from molecular dynamics simulations.Oxidation of endogenous N-arachidonoylserotonin by human cytochrome P450 2U1.In Situ Proteolysis for Crystallization of Membrane Bound Cytochrome P450 17A1 and 17A2 Proteins from Zebrafish.Transmembrane Interactions of Full-length Mammalian Bitopic Cytochrome-P450-Cytochrome-b5 Complex in Lipid Bilayers Revealed by Sensitivity-Enhanced Dynamic Nuclear Polarization Solid-state NMR Spectroscopy.Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes.Membrane Interactions, Ligand-Dependent Dynamics, and Stability of Cytochrome P4503A4 in Lipid Nanodiscs.A natural heme-signature variant of CYP267A1 from Sorangium cellulosum So ce56 executes diverse ω-hydroxylation.Lipid molecules can induce an opening of membrane-facing tunnels in cytochrome P450 1A2.Evolutionary origin of mitochondrial cytochrome P450.The X-Ray Crystal Structure of the Human Mono-Oxygenase Cytochrome P450 3A5-Ritonavir Complex Reveals Active Site Differences between P450s 3A4 and 3A5.

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P2860

Structural diversity of eukaryotic membrane cytochrome p450s

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2013 nî lūn-bûn

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2013 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2013 թվականի հունիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Structural diversity of eukaryotic membrane cytochrome p450s

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Structural diversity of eukaryotic membrane cytochrome p450s

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Structural diversity of eukaryotic membrane cytochrome p450s

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Structural diversity of eukaryotic membrane cytochrome p450s

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Structural diversity of eukaryotic membrane cytochrome p450s

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Structural diversity of eukaryotic membrane cytochrome p450s

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Structural diversity of eukaryotic membrane cytochrome p450s

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Structural diversity of eukaryotic membrane cytochrome p450s

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Journal of Biological Chemistry

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Structural diversity of eukaryotic membrane cytochrome p450s

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C. D. Stout

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E. F. Johnson

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P2860

Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain

Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution

Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2

Crystal structure of human cytochrome P450 2D6

Structural basis of human CYP51 inhibition by antifungal azoles

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19

Structure of the human lung cytochrome P450 2A13

Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001

Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system

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