Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer - Wikidata - awgldk - TriplyDB

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

http://www.wikidata.org/entity/Q27682064

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Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase.Expanding the Binding Envelope of CYP51 Inhibitors TargetingTrypanosoma cruziwith 4-Aminopyridyl-Based Sulfonamide Derivatives Cytochrome P450 monooxygenase CYP53 family in fungi: comparative structural and evolutionary analysis and its role as a common alternative anti-fungal drug target Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals Clinical implications of globally emerging azole resistance in Aspergillus fumigatus.The CYP51F1 Gene of Leptographium qinlingensis: Sequence Characteristic, Phylogeny and Transcript Levels.The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ω-Hydroxylation.Resistance to antifungals that target CYP51.The X-ray structure of NccX from Cupriavidus metallidurans 31A illustrates potential dangers of detergent solubilization when generating and interpreting crystal structures of membrane proteins.Drug strategies targeting CYP51 in neglected tropical diseases Interactions among cytochromes P450 in microsomal membranes: oligomerization of cytochromes P450 3A4, 3A5, and 2E1 and its functional consequences Dynamics of CYP51: implications for function and inhibitor design.Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase.Azole fungicides - understanding resistance mechanisms in agricultural fungal pathogens.Structural characterization of human cholesterol 7α-hydroxylase Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.Activity of Isavuconazole and Other Azoles against Candida Clinical Isolates and Yeast Model Systems with Known Azole Resistance Mechanisms.Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase Membrane Fluidity Modulates Thermal Stability and Ligand Binding of Cytochrome P4503A4 in Lipid Nanodiscs.Examining how enzymes self-organize in a membrane.Multiple mechanisms contribute to the development of clinically significant azole resistance in Aspergillus fumigatus.Medically important fungi respond to azole drugs: an update.Isavuconazole: Pharmacology, Pharmacodynamics, and Current Clinical Experience with a New Triazole Antifungal Agent.Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus.Rapid Chagas Disease Drug Target Discovery Using Directed Evolution in Drug-Sensitive Yeast.Gene duplication leads to altered membrane topology of a cytochrome P450 enzyme in seed plants.Strategies in the discovery of novel antifungal scaffolds.Targeting CYP51 for drug design by the contributions of molecular modeling.Pan-azole-resistant Candida tropicalis carrying homozygous erg11 mutations at position K143R: a new emerging superbug?Divergent mechanisms of iron-containing enzymes for hydrocarbon biosynthesis.Repositioning of Endonuclear Receptors Binders as Potential Antibacterial and Antifungal Agents. Eptyloxìm: A Potential and Novel Gyrase B and Cytochrome Cyp51 Inhibitor.The amino acid substitution N136Y in Candida albicans sterol 14alpha-demethylase is involved in fluconazole resistance.Exploring the thiazole scaffold for the identification of new agents for the treatment of fluconazole resistant Candida.In Situ Proteolysis for Crystallization of Membrane Bound Cytochrome P450 17A1 and 17A2 Proteins from Zebrafish.Small-angle scattering determination of the shape and localization of human cytochrome P450 embedded in a phospholipid nanodisc environment.ERG11 mutations and expression of resistance genes in fluconazole-resistant Candida albicans isolates.Stepwise design, synthesis, and in vitro antifungal screening of (Z)-substituted-propenoic acid derivatives with potent broad-spectrum antifungal activity Candida parapsilosis Resistance to Fluconazole: Molecular Mechanisms and In Vivo Impact in Infected Galleria mellonella Larvae.A strategy for analyzing bond strength and interaction kinetics between Pleckstrin homology domains and PI(4,5)P2 phospholipids using force distance spectroscopy and surface plasmon resonance.Identification of universal selectivity-determining positions in cytochrome P450 monooxygenases by systematic sequence-based literature mining.

P2860

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P2860

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

http://www.wikidata.org/entity/Q27682064

description

2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年论文

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Architecture of a single membr ...... c domain relative to a bilayer

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Architecture of a single membr ...... c domain relative to a bilayer

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Architecture of a single membr ...... c domain relative to a bilayer

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Architecture of a single membr ...... c domain relative to a bilayer

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Architecture of a single membr ...... c domain relative to a bilayer

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Architecture of a single membr ...... c domain relative to a bilayer

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Architecture of a single membr ...... c domain relative to a bilayer

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Architecture of a single membr ...... c domain relative to a bilayer

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PNAS.1324245111

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Proceedings of the National Academy of Sciences of the United States of America

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Architecture of a single membr ...... c domain relative to a bilayer

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Andrew Rodriguez

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Brian C Monk

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Franziska U Huschmann

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Janet S Finer-Moore

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Jeffrey G McDonald

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Joseph D O'Connell

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Robert M Stroud

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Thomas M Tomasiak

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P2860

DelPhi: a comprehensive suite for DelPhi software and associated resources

Structural basis of human CYP51 inhibition by antifungal azoles

Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone

Structures of human microsomal cytochrome P450 2A6 complexed with coumarin and methoxsalen

Structural basis for androgen specificity and oestrogen synthesis in human aromatase

Anisotropic solvent model of the lipid bilayer. 2. Energetics of insertion of small molecules, peptides, and proteins in membranes

CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds

Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

MolProbity: all-atom structure validation for macromolecular crystallography

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3865-3870

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1568127

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Richard D. Cannon

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260682426

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