MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis
about
p53 Stabilization and accumulation induced by human vaccinia-related kinase 1MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathwaySALL4 is a key regulator of survival and apoptosis in human leukemic cellsPredicted functions of MdmX in fine-tuning the response of p53 to DNA damage.c-Abl phosphorylation of Mdm2 facilitates Mdm2-Mdmx complex formation.Role of an MDM4 polymorphism in the early age of onset of nasopharyngeal carcinomaHypoxia Promotes Synergy between Mitomycin C and Bortezomib through a Coordinated Process of Bcl-xL Phosphorylation and Mitochondrial Translocation of p53.MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage responseAnalysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties.Suppression of the mouse double minute 4 gene causes changes in cell cycle control in a human mesothelial cell line responsive to ultraviolet radiation exposure.Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53.Functions of MDMX in the modulation of the p53-response.Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondriaMDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond.Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma.Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry.Guarding the guardian: Mdmx plays important roles in setting p53 basal activity and determining biological responses in vivoOn the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study.Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.Mdmx: a p53 activator?
P2860
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P2860
MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis
description
2004 nî lūn-bûn
@nan
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
MDM4 (MDMX) overexpression enh ...... ced p53 and promotes apoptosis
@ast
MDM4 (MDMX) overexpression enh ...... ced p53 and promotes apoptosis
@en
MDM4 (MDMX) overexpression enh ...... ced p53 and promotes apoptosis
@en-gb
MDM4 (MDMX) overexpression enh ...... ced p53 and promotes apoptosis
@nl
type
label
MDM4 (MDMX) overexpression enh ...... ced p53 and promotes apoptosis
@ast
MDM4 (MDMX) overexpression enh ...... ced p53 and promotes apoptosis
@en
MDM4 (MDMX) overexpression enh ...... ced p53 and promotes apoptosis
@en-gb
MDM4 (MDMX) overexpression enh ...... ced p53 and promotes apoptosis
@nl
prefLabel
MDM4 (MDMX) overexpression enh ...... ced p53 and promotes apoptosis
@ast
MDM4 (MDMX) overexpression enh ...... ced p53 and promotes apoptosis
@en
MDM4 (MDMX) overexpression enh ...... ced p53 and promotes apoptosis
@en-gb
MDM4 (MDMX) overexpression enh ...... ced p53 and promotes apoptosis
@nl
P2093
P2860
P50
P921
P356
P1476
MDM4 (MDMX) overexpression enh ...... ced p53 and promotes apoptosis
@en
P2093
Alfredo Pontecorvi
Antonella Farsetti
Carmen D'Angelo
Gennaro Citro
Marco D'Angelo
Simona Nanni
P2860
P304
P356
10.1074/JBC.M311793200
P407
P577
2004-02-27T00:00:00Z