Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.
about
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathwayDeletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.MDM2 oligomers: antagonizers of the guardian of the genome.Limiting the power of p53 through the ubiquitin proteasome pathway.It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.The Roles of MDM2 and MDMX Phosphorylation in Stress Signaling to p53.MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice.Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?MdmX regulates transformation and chromosomal stability in p53-deficient cells.A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancerUsing Mouse Models to Explore MDM-p53 Signaling in Development, Cell Growth, and Tumorigenesis.Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy.Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondriaMouse modelling of the MDM2/MDMX-p53 signalling axis.Targeting MDM4 Splicing in Cancers.Mdm2 Splice isoforms regulate the p53/Mdm2/Mdm4 regulatory circuit via RING domain-mediated ubiquitination of p53 and Mdm4.Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma.Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity of RING finger mutants of Mdm2.Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafishWidespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivoMice engineered for an obligatory Mdm4 exon skipping express higher levels of the Mdm4-S isoform but exhibit increased p53 activity.The Roles of MDM2 and MDMX in Cancer.
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P2860
Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
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name
Rescue of Mdm4-deficient mice ...... Mdm2 and Mdm4 in development.
@en
Rescue of Mdm4-deficient mice ...... Mdm2 and Mdm4 in development.
@nl
type
label
Rescue of Mdm4-deficient mice ...... Mdm2 and Mdm4 in development.
@en
Rescue of Mdm4-deficient mice ...... Mdm2 and Mdm4 in development.
@nl
prefLabel
Rescue of Mdm4-deficient mice ...... Mdm2 and Mdm4 in development.
@en
Rescue of Mdm4-deficient mice ...... Mdm2 and Mdm4 in development.
@nl
P2093
P2860
P356
P1433
P1476
Rescue of Mdm4-deficient mice ...... Mdm2 and Mdm4 in development.
@en
P2093
Arthur T Sands
Heather A Steinman
Kathleen M Hoover
Marilyn L Keeler
Stephen N Jones
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P2888
P304
P356
10.1038/SJ.ONC.1208930
P407
P577
2005-11-01T00:00:00Z
P5875
P6179
1018161133