The BRCA2 gene product functionally interacts with p53 and RAD51 - Wikidata - awgldk - TriplyDB

The BRCA2 gene product functionally interacts with p53 and RAD51

The BRCA2 gene product functionally interacts with p53 and RAD51

http://www.wikidata.org/entity/Q24650406

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Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium BRCA2 and homologous recombination Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2 Purified human BRCA2 stimulates RAD51-mediated recombination CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage Highlight: BRCA1 and BRCA2 proteins in breast cancer Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining Trypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombination Abrogation of the transactivation activity of p53 by BCCIP down-regulation Role of BRCA gene dysfunction in breast and ovarian cancer predisposition.Genetic Stabilization by p53 Involves Growth Regulatory and Repair Pathways Assembly of RecA-like recombinases: distinct roles for mediator proteins in mitosis and meiosis Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2 Protective role of miR-155 in breast cancer through RAD51 targeting impairs homologous recombination after irradiation Analysis of ARD1 function in hypoxia response using retroviral RNA interference Mouse models of Fanconi anemia Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways Homologs of breast cancer genes in plants RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair.Functional connection between Rad51 and PML in homology-directed repair.Regulation of Sp1 by cell cycle related proteins.Bestrophin-2 is involved in the generation of intraocular pressure.BRCA1, BRCA2 and their possible function in DNA damage response EMSY overexpression disrupts the BRCA2/RAD51 pathway in the DNA-damage response: implications for chromosomal instability/recombination syndromes as checkpoint diseases.The BRCA2 activation domain associates with and is phosphorylated by a cellular protein kinase.Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2.Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences.Interaction with BRCA2 suggests a role for filamin-1 (hsFLNa) in DNA damage response.BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair.Lessons learned from BRCA1 and BRCA2.Multiple pathway-based genetic variations associated with tobacco related multiple primary neoplasms.BRCA2 and Smad3 synergize in regulation of gene transcription.Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major.BRCA2 is a mediator of RAD51- and DMC1-facilitated homologous recombination in Arabidopsis thaliana.

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P2860

The BRCA2 gene product functionally interacts with p53 and RAD51

http://www.wikidata.org/entity/Q24650406

description

1998 nî lūn-bûn

@nan

1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

1998年の論文

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1998年論文

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1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

The BRCA2 gene product functionally interacts with p53 and RAD51

@ast

The BRCA2 gene product functionally interacts with p53 and RAD51

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The BRCA2 gene product functionally interacts with p53 and RAD51

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type

label

The BRCA2 gene product functionally interacts with p53 and RAD51

@ast

The BRCA2 gene product functionally interacts with p53 and RAD51

@en

The BRCA2 gene product functionally interacts with p53 and RAD51

@nl

prefLabel

The BRCA2 gene product functionally interacts with p53 and RAD51

@ast

The BRCA2 gene product functionally interacts with p53 and RAD51

@en

The BRCA2 gene product functionally interacts with p53 and RAD51

@nl

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PNAS.95.23.13869

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Proceedings of the National Academy of Sciences of the United States of America

P1476

The BRCA2 gene product functionally interacts with p53 and RAD51

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P2093

L Y Marmorstein

http://www.w3.org/2001/XMLSchema#string

S A Aaronson

http://www.w3.org/2001/XMLSchema#string

T Ouchi

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P2860

Interaction of p53 with the human Rad51 protein

The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

Transcriptional activation functions in BRCA2

p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction

p53, the cellular gatekeeper for growth and division

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein

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13869-74

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scholarly article

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3452415

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10.1073/PNAS.95.23.13869

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