An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure
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Cellular Biomechanics in Drug Screening and Evaluation: MechanopharmacologyCalcium influx pathways in breast cancer: opportunities for pharmacological interventionCartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related OsteoarthritisPharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic miceOrgans-on-chips at the frontiers of drug discoveryTACTIC: Trans-Agency Consortium for Trauma-Induced CoagulopathyAn Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness.Prevention of ventilator-induced lung edema by inhalation of nanoparticles releasing ruthenium red.The puzzle of TRPV4 channelopathies.Transient receptor potential (TRP) channels: a clinical perspectiveTransient receptor potential (TRP) channels in the airway: role in airway disease.Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations.Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary EdemaVasodilator responses to acetylcholine are not mediated by the activation of soluble guanylate cyclase or TRPV4 channels in the rat.Calcineurin/nuclear factor of activated T cells-coupled vanilliod transient receptor potential channel 4 ca2+ sparklets stimulate airway smooth muscle cell proliferationTransient receptor potential channels and regulation of lung endothelial permeability.Primary cilia signaling mediates intraocular pressure sensation.Vascular TRP channels: performing under pressure and going with the flowRole of TRP channels in the cardiovascular system.Deciphering physiological role of the mechanosensitive TRPV4 channel in the distal nephron.TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice.TRPV4 as a therapeutic target for joint diseases.Functional coupling of TRPV4, IK, and SK channels contributes to Ca(2+)-dependent endothelial injury in rodent lungShear stress mediates exocytosis of functional TRPV4 channels in endothelial cells.Transient receptor potential channels in the vasculature.Genetic deficit of KCa 3.1 channels protects against pulmonary circulatory collapse induced by TRPV4 channel activation.New therapeutic targets in rare genetic skeletal diseases.Hydrogen peroxide-induced calcium influx in lung microvascular endothelial cells involves TRPV4.TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis.Transient receptor potential (TRP) channels as a therapeutic target for intervention of respiratory effects and lethality from phosgene.Unraveling the mechanism by which TRPV4 mutations cause skeletal dysplasias.Activation of TRPV4 Regulates Respiration through Indirect Activation of Bronchopulmonary Sensory Neurons.Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: Role of adenosine triphosphate.Endothelial TRPV4 channels mediate dilation of cerebral arteries: impairment and recovery in cerebrovascular pathologies related to Alzheimer's diseaseTRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension.A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis.Blockage of transient receptor potential vanilloid 4 alleviates myocardial ischemia/reperfusion injury in mice.Transient receptor potential vanilloid 4 activation constricts the human bronchus via the release of cysteinyl leukotrienesCharacterization of blood pressure and endothelial function in TRPV4-deficient mice with l-NAME- and angiotensin II-induced hypertension.Causes and treatment of oedema in patients with heart failure.
P2860
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P2860
An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
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2012年学术文章
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2012年学术文章
@zh-cn
2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年學術文章
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name
An orally active TRPV4 channel ...... edema induced by heart failure
@ast
An orally active TRPV4 channel ...... edema induced by heart failure
@en
An orally active TRPV4 channel ...... edema induced by heart failure
@en-gb
An orally active TRPV4 channel ...... edema induced by heart failure
@nl
type
label
An orally active TRPV4 channel ...... edema induced by heart failure
@ast
An orally active TRPV4 channel ...... edema induced by heart failure
@en
An orally active TRPV4 channel ...... edema induced by heart failure
@en-gb
An orally active TRPV4 channel ...... edema induced by heart failure
@nl
prefLabel
An orally active TRPV4 channel ...... edema induced by heart failure
@ast
An orally active TRPV4 channel ...... edema induced by heart failure
@en
An orally active TRPV4 channel ...... edema induced by heart failure
@en-gb
An orally active TRPV4 channel ...... edema induced by heart failure
@nl
P2093
P921
P3181
P1476
An orally active TRPV4 channel ...... edema induced by heart failure
@en
P2093
Alan Olzinski
Anna Waszkiewicz
Beat M Jucker
Brian Donovan
Chris James
Christine G Schnackenberg
Daniel S Matasic
Earl Gordon
Elizabeth A Davenport
P2860
P304
P3181
P356
10.1126/SCITRANSLMED.3004276
P407
P577
2012-11-07T00:00:00Z