Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis - Wikidata - awgldk - TriplyDB

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

http://www.wikidata.org/entity/Q24614844

about

An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure Authentic role of ATP signaling in micturition reflex.TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye.Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.Transient receptor potential channels as therapeutic targets Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations Urothelial signaling.The Concise Guide to PHARMACOLOGY 2013/14: ion channels Optical recording reveals novel properties of GSK1016790A-induced vanilloid transient receptor potential channel TRPV4 activity in primary human endothelial cells.TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses.Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion.TRPV1 and TRPV4 play pivotal roles in delayed onset muscle soreness.The puzzle of TRPV4 channelopathies.Transient receptor potential (TRP) channels: a clinical perspective TRP channels in lower urinary tract dysfunction.Calcineurin/nuclear factor of activated T cells-coupled vanilliod transient receptor potential channel 4 ca2+ sparklets stimulate airway smooth muscle cell proliferation Altered detrusor gap junction communications induce storage symptoms in bladder inflammation: a mouse cyclophosphamide-induced model of cystitis.The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo Intravesical TRPV4 blockade reduces repeated variate stress-induced bladder dysfunction by increasing bladder capacity and decreasing voiding frequency in male rats Bladder sensory physiology: neuroactive compounds and receptors, sensory transducers, and target-derived growth factors as targets to improve function.Vascular TRP channels: performing under pressure and going with the flow TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia.Receptors, channels, and signalling in the urothelial sensory system in the bladder Mutant TRPV4-mediated toxicity is linked to increased constitutive function in axonal neuropathies.Acupuncture for visceral pain: neural substrates and potential mechanisms.TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.Deciphering physiological role of the mechanosensitive TRPV4 channel in the distal nephron.Temperature oscillations drive cycles in the activity of MMP-2,9 secreted by a human trabecular meshwork cell line.Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia.TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice.TRP Channels Localize to Subdomains of the Apical Plasma Membrane in Human Fetal Retinal Pigment Epithelium TRPV4 and K(Ca) ion channels functionally couple as osmosensors in the paraventricular nucleus Functional coupling of TRPV4, IK, and SK channels contributes to Ca(2+)-dependent endothelial injury in rodent lung Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth.Transient receptor potential channels in the vasculature.TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes Apigenin, a plant-derived flavone, activates transient receptor potential vanilloid 4 cation channel.Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas

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P2860

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

http://www.wikidata.org/entity/Q24614844

description

2010 nî lūn-bûn

@nan

2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Inhibition of the cation chann ...... lophosphamide-induced cystitis

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Inhibition of the cation chann ...... lophosphamide-induced cystitis

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Inhibition of the cation chann ...... lophosphamide-induced cystitis

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Inhibition of the cation chann ...... lophosphamide-induced cystitis

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Inhibition of the cation chann ...... lophosphamide-induced cystitis

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Inhibition of the cation chann ...... lophosphamide-induced cystitis

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Inhibition of the cation chann ...... lophosphamide-induced cystitis

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Inhibition of the cation chann ...... lophosphamide-induced cystitis

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Inhibition of the cation chann ...... lophosphamide-induced cystitis

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PNAS.1005333107

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Proceedings of the National Academy of Sciences of the United States of America

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Inhibition of the cation chann ...... lophosphamide-induced cystitis

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Christopher M Fanger

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Colleen R McNamara

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Debapriya Ghosh

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Eda Uykal

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Fenqin Xue

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James P Gilbert

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Magdalene M Moran

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Neil J Hayward

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Thomas Gevaert

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Timothy Strassmaier

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P2860

Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C

The neural control of micturition

Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C

The concept of neurogenic inflammation

Transient receptor potential cation channels in disease

Cyclophosphamide cystitis--identification of acrolein as the causative agent

PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4

Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3

Impaired osmotic sensation in mice lacking TRPV4

Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice

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19084-9

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scholarly article

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10.1073/PNAS.1005333107

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44

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107

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Grzegorz Owsianik

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2010-11-02T00:00:00Z

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47459287

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20956320

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2973867

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