FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway
about
Spartan/C1orf124 is important to prevent UV-induced mutagenesisA ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair networkBreast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repairMolecular pathogenesis and clinical management of Fanconi anemiaStructure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage responseStructural insights into the functions of the FANCM-FAAP24 complex in DNA repairMechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3Biophysical characterization of the interaction between FAAP20-UBZ4 domain and Rev1-BRCT domainForkhead transcription factor FoxF1 interacts with Fanconi anemia protein complexes to promote DNA damage responseAluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.ATR-dependent phosphorylation of FANCM at serine 1045 is essential for FANCM functions.The genetic and biochemical basis of FANCD2 monoubiquitinationRegulation of DNA cross-link repair by the Fanconi anemia/BRCA pathwayA protein prioritization approach tailored for the FA/BRCA pathway.Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain.RNF4-mediated polyubiquitination regulates the Fanconi anemia/BRCA pathway.Defective FANCI binding by a fanconi anemia-related FANCD2 mutant.Structural basis for ubiquitin recognition by ubiquitin-binding zinc finger of FAAP20.Human FAN1 promotes strand incision in 5'-flapped DNA complexed with RPA.Loss of Faap20 Causes Hematopoietic Stem and Progenitor Cell Depletion in Mice Under Genotoxic Stress.Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.FANCM and FAAP24 maintain genome stability via cooperative as well as unique functionsThe Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma.DNA damage tolerance: a double-edged sword guarding the genomeMonopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III α-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activatioBloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinksMaintenance of genome stability by Fanconi anemia proteins.The Fanconi anemia pathway in replication stress and DNA crosslink repair.REV1 and DNA polymerase zeta in DNA interstrand crosslink repair.The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability.TNF-α signaling in Fanconi anemia.Stress and DNA repair biology of the Fanconi anemia pathwayThe Fanconi anemia ID2 complex: dueling saxes at the crossroads.RNA interferences targeting the Fanconi anemia/BRCA pathway upstream genes reverse cisplatin resistance in drug-resistant lung cancer cells.Ubiquitin-like protein UBL5 promotes the functional integrity of the Fanconi anemia pathway.Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair.FBW7 regulates DNA interstrand cross-link repair by modulating FAAP20 degradation.Modularized functions of the Fanconi anemia core complex.Targeting the fanconi anemia pathway to identify tailored anticancer therapeutics.Towards a molecular understanding of the fanconi anemia core complex
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P2860
FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
FAAP20: a novel ubiquitin-bind ...... the FA-BRCA DNA repair pathway
@ast
FAAP20: a novel ubiquitin-bind ...... the FA-BRCA DNA repair pathway
@en
FAAP20: a novel ubiquitin-bind ...... the FA-BRCA DNA repair pathway
@en-gb
FAAP20: a novel ubiquitin-bind ...... the FA-BRCA DNA repair pathway
@nl
type
label
FAAP20: a novel ubiquitin-bind ...... the FA-BRCA DNA repair pathway
@ast
FAAP20: a novel ubiquitin-bind ...... the FA-BRCA DNA repair pathway
@en
FAAP20: a novel ubiquitin-bind ...... the FA-BRCA DNA repair pathway
@en-gb
FAAP20: a novel ubiquitin-bind ...... the FA-BRCA DNA repair pathway
@nl
prefLabel
FAAP20: a novel ubiquitin-bind ...... the FA-BRCA DNA repair pathway
@ast
FAAP20: a novel ubiquitin-bind ...... the FA-BRCA DNA repair pathway
@en
FAAP20: a novel ubiquitin-bind ...... the FA-BRCA DNA repair pathway
@en-gb
FAAP20: a novel ubiquitin-bind ...... the FA-BRCA DNA repair pathway
@nl
P2093
P2860
P921
P3181
P1433
P1476
FAAP20: a novel ubiquitin-bind ...... the FA-BRCA DNA repair pathway
@en
P2093
Amom Ruhikanta Meetei
Arun Pradhan
Changhu Du
Elke Grassman
Kebola Wahengbam
Qishen Pang
Thiyam Ramsingh Singh
P2860
P304
P3181
P356
10.1182/BLOOD-2011-10-385963
P407
P577
2012-02-17T00:00:00Z