Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence
about
Unraveling the specificity of heparanase utilizing synthetic substrates.Structural characterization of human heparanase reveals insights into substrate recognition.A liquid chromatography-mass spectrometry-based approach to characterize the substrate specificity of mammalian heparanase.Mammalian heparanase: what is the message?Distribution of Heparan Sulfate Oligosaccharides in Murine Mucopolysaccharidosis Type IIIASynthesis of a pseudo-disaccharide library and its application to the characterisation of the heparanase catalytic siteFGF2 binding, signaling, and angiogenesis are modulated by heparanase in metastatic melanoma cellsExpression of heparanase in vascular cells and astrocytes of the mouse brain after focal cerebral ischemia.Heparanase as a molecular target of cancer chemotherapy.Deciphering mode of action of heparanase using structurally defined oligosaccharides.The Responses of Hyperglycemic Dividing Mesangial Cells to Heparin Are Mediated by the Non-reducing Terminal Trisaccharide.Human follicular fluid heparan sulfate contains abundant 3-O-sulfated chains with anticoagulant activity.Molecular structure of heparan sulfate from Spalax. Implications of heparanase and hypoxia.Method development and analysis of free HS and HS in proteoglycans from pre- and postmenopausal women: evidence for biosynthetic pathway changes in sulfotransferase and sulfatase enzymes.Heparin-derived heparan sulfate mimics to modulate heparan sulfate-protein interaction in inflammation and cancer.Microbial heparin/heparan sulphate lyases: potential and applications.Heparan sulfate inhibitors and their therapeutic implications in inflammatory illnesses.The mechanisms and physiological relevance of glycocalyx degradation in hepatic ischemia/reperfusion injury.Oxidation and modification of extracellular matrix and its role in disease.The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics.Molecular model of human heparanase with proposed binding mode of a heparan sulfate oligosaccharide and catalytic amino acids.Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-β-D-glucuronidase (heparanase).Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease.Epigenetic Regulation of the Biosynthesis & Enzymatic Modification of Heparan Sulfate Proteoglycans: Implications for Tumorigenesis and Cancer Biomarkers.Localization of heparanase in esophageal cancer cells: respective roles in prognosis and differentiation.Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase.Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells.Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues.Heparanase: From basic research to therapeutic applications in cancer and inflammation.Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence.Synthesis of simple heparanase substrates.Proteoglycan UDP-galactose:beta-xylose beta 1,4-galactosyltransferase I is essential for viability in Drosophila melanogaster.Liquid chromatography/mass spectrometry sequencing approach for highly sulfated heparin-derived oligosaccharides.Molecular characterization, expression profiles, and association analysis with hematologic parameters of the porcine HPSE and HPSE2 genes.Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting.Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats.Heparanase neutralizes the anticoagulation properties of heparin and low-molecular-weight heparin.Cloning and bacterial expression systems for recombinant human heparanase production: Substrate specificity investigation by docking of a putative heparanase substrate.Investigating Glycol-Split-Heparin-Derived Inhibitors of Heparanase: A Study of Synthetic Trisaccharides
P2860
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P2860
Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Structural recognition by reco ...... ulfated trisaccharide sequence
@ast
Structural recognition by reco ...... ulfated trisaccharide sequence
@en
Structural recognition by reco ...... ulfated trisaccharide sequence
@en-gb
Structural recognition by reco ...... ulfated trisaccharide sequence
@nl
type
label
Structural recognition by reco ...... ulfated trisaccharide sequence
@ast
Structural recognition by reco ...... ulfated trisaccharide sequence
@en
Structural recognition by reco ...... ulfated trisaccharide sequence
@en-gb
Structural recognition by reco ...... ulfated trisaccharide sequence
@nl
prefLabel
Structural recognition by reco ...... ulfated trisaccharide sequence
@ast
Structural recognition by reco ...... ulfated trisaccharide sequence
@en
Structural recognition by reco ...... ulfated trisaccharide sequence
@en-gb
Structural recognition by reco ...... ulfated trisaccharide sequence
@nl
P2093
P2860
P356
P1476
Structural recognition by reco ...... ulfated trisaccharide sequence
@en
P2093
Kazuyuki Sugahara
Minako Toyoshima
Motowo Nakajima
Shuhei Yamada
Yukihiko Okada
P2860
P304
P356
10.1074/JBC.M206510200
P407
P577
2002-11-08T00:00:00Z